Trajectories of Biological Values and Vital Parameters: An Observational Cohort Study of Adult Patients with Sickle Cell Disease Hospitalized for a Non-Complicated Vaso-Occlusive Crisis
Hospital admission of patients with sickle-cell disease (SCD) presenting with a vaso-occlusive crisis (VOC) can be justified by pain refractory to usual outpatient care and/or the occurrence of a complication. Yet, the trajectories of vital parameters and standard biomarkers throughout a non-complic...
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doaj-f81fad723f9546e6ae0cf10fd6daadd32020-11-25T02:47:35ZengMDPI AGJournal of Clinical Medicine2077-03832019-09-0189150210.3390/jcm8091502jcm8091502Trajectories of Biological Values and Vital Parameters: An Observational Cohort Study of Adult Patients with Sickle Cell Disease Hospitalized for a Non-Complicated Vaso-Occlusive CrisisRaphael Veil0Simon Bussy1Vincent Looten2Jean-Benoît Arlet3Jacques Pouchot4Anne-Sophie Jannot5Brigitte Ranque6Medical Information Department, Georges Pompidou European Hospital, AP-HP, 75015 Paris, FranceLPSM, CNRS UMR 8001, Sorbonne University, 75005, Paris, FranceMedical Information Department, Georges Pompidou European Hospital, AP-HP, 75015 Paris, FranceInternal Medicine Department, Sickle Cell Referral Center, Georges Pompidou European Hospital, AP-HP, 75015 Paris, FranceInternal Medicine Department, Sickle Cell Referral Center, Georges Pompidou European Hospital, AP-HP, 75015 Paris, FranceMedical Information Department, Georges Pompidou European Hospital, AP-HP, 75015 Paris, FranceInternal Medicine Department, Sickle Cell Referral Center, Georges Pompidou European Hospital, AP-HP, 75015 Paris, FranceHospital admission of patients with sickle-cell disease (SCD) presenting with a vaso-occlusive crisis (VOC) can be justified by pain refractory to usual outpatient care and/or the occurrence of a complication. Yet, the trajectories of vital parameters and standard biomarkers throughout a non-complicated VOC has not been established. In this observational cohort study, we describe the course of routine parameters throughout 329 hospital stays for non-complicated VOC. We used a new spline-based approach to study and visualize non-specific time-dependent variables extracted from the hospital clinical data warehouse. We identified distinct trends during the VOC for hemoglobin level, leukocytes count, C-Reactive Protein (CRP) level and temperature. Hemoglobin decreased after admission and rarely returned to steady state levels before discharge. White blood cell counts were elevated at admission before immediately decreasing, whereas eosinophils increased slowly throughout the first five days of the stay. In over 95% of non-complicated VOC-related stays, the CRP value was below 100 mg/L within the first day following admission and above normal after 48 hours, and the temperature was below 38 °C throughout the entire stay. Knowing the typical trajectories of these routine parameters during non-complicated VOC may urge the clinicians to be more vigilant in case of deviation from these patterns.https://www.mdpi.com/2077-0383/8/9/1502humansadultsred cellshemoglobinopathiesanemiasickle cellbio-monitoringhospitalization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raphael Veil Simon Bussy Vincent Looten Jean-Benoît Arlet Jacques Pouchot Anne-Sophie Jannot Brigitte Ranque |
spellingShingle |
Raphael Veil Simon Bussy Vincent Looten Jean-Benoît Arlet Jacques Pouchot Anne-Sophie Jannot Brigitte Ranque Trajectories of Biological Values and Vital Parameters: An Observational Cohort Study of Adult Patients with Sickle Cell Disease Hospitalized for a Non-Complicated Vaso-Occlusive Crisis Journal of Clinical Medicine humans adults red cells hemoglobinopathies anemia sickle cell bio-monitoring hospitalization |
author_facet |
Raphael Veil Simon Bussy Vincent Looten Jean-Benoît Arlet Jacques Pouchot Anne-Sophie Jannot Brigitte Ranque |
author_sort |
Raphael Veil |
title |
Trajectories of Biological Values and Vital Parameters: An Observational Cohort Study of Adult Patients with Sickle Cell Disease Hospitalized for a Non-Complicated Vaso-Occlusive Crisis |
title_short |
Trajectories of Biological Values and Vital Parameters: An Observational Cohort Study of Adult Patients with Sickle Cell Disease Hospitalized for a Non-Complicated Vaso-Occlusive Crisis |
title_full |
Trajectories of Biological Values and Vital Parameters: An Observational Cohort Study of Adult Patients with Sickle Cell Disease Hospitalized for a Non-Complicated Vaso-Occlusive Crisis |
title_fullStr |
Trajectories of Biological Values and Vital Parameters: An Observational Cohort Study of Adult Patients with Sickle Cell Disease Hospitalized for a Non-Complicated Vaso-Occlusive Crisis |
title_full_unstemmed |
Trajectories of Biological Values and Vital Parameters: An Observational Cohort Study of Adult Patients with Sickle Cell Disease Hospitalized for a Non-Complicated Vaso-Occlusive Crisis |
title_sort |
trajectories of biological values and vital parameters: an observational cohort study of adult patients with sickle cell disease hospitalized for a non-complicated vaso-occlusive crisis |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-09-01 |
description |
Hospital admission of patients with sickle-cell disease (SCD) presenting with a vaso-occlusive crisis (VOC) can be justified by pain refractory to usual outpatient care and/or the occurrence of a complication. Yet, the trajectories of vital parameters and standard biomarkers throughout a non-complicated VOC has not been established. In this observational cohort study, we describe the course of routine parameters throughout 329 hospital stays for non-complicated VOC. We used a new spline-based approach to study and visualize non-specific time-dependent variables extracted from the hospital clinical data warehouse. We identified distinct trends during the VOC for hemoglobin level, leukocytes count, C-Reactive Protein (CRP) level and temperature. Hemoglobin decreased after admission and rarely returned to steady state levels before discharge. White blood cell counts were elevated at admission before immediately decreasing, whereas eosinophils increased slowly throughout the first five days of the stay. In over 95% of non-complicated VOC-related stays, the CRP value was below 100 mg/L within the first day following admission and above normal after 48 hours, and the temperature was below 38 °C throughout the entire stay. Knowing the typical trajectories of these routine parameters during non-complicated VOC may urge the clinicians to be more vigilant in case of deviation from these patterns. |
topic |
humans adults red cells hemoglobinopathies anemia sickle cell bio-monitoring hospitalization |
url |
https://www.mdpi.com/2077-0383/8/9/1502 |
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