Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

A pyrimidinethione derivative namely, 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile, was readily synthesized and reacted with carbon electrophiles in an attempt to synthesize selected fused heterocycles. The reactivity of 6-(1,3-diphenyl-1H-pyrazol-4-yl)...

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Main Authors:	Ramadan Sayed K., El-Helw Eman A. E., Sallam Hanan A.
Format:	Article
Language:	English
Published:	De Gruyter 2019-11-01
Series:	Heterocyclic Communications
Subjects:	antitumor and antimicrobial activity carbon electrophiles tetrahydropyrimidine thiation thiazolopyrimidine
Online Access:	https://doi.org/10.1515/hc-2019-0008

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spelling	doaj-f8238899570b4533934653ddcff9e8182021-09-06T19:19:48ZengDe GruyterHeterocyclic Communications2191-01972019-11-0125110711510.1515/hc-2019-0008Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrileRamadan Sayed K.0El-Helw Eman A. E.1Sallam Hanan A.2Chemistry Department, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, EgyptChemistry Department, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, EgyptChemistry Department, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, EgyptA pyrimidinethione derivative namely, 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile, was readily synthesized and reacted with carbon electrophiles in an attempt to synthesize selected fused heterocycles. The reactivity of 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile was investigated towards selected nitrogen nucleophiles. Thiation and hydrolysis reactions of the tetrahydropyrimidine derivative were investigated. Antitumor and antimicrobial activity evaluation of some of the synthesized products exhibited promising results.https://doi.org/10.1515/hc-2019-0008antitumor and antimicrobial activitycarbon electrophilestetrahydropyrimidinethiationthiazolopyrimidine
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ramadan Sayed K. El-Helw Eman A. E. Sallam Hanan A.
spellingShingle	Ramadan Sayed K. El-Helw Eman A. E. Sallam Hanan A. Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile Heterocyclic Communications antitumor and antimicrobial activity carbon electrophiles tetrahydropyrimidine thiation thiazolopyrimidine
author_facet	Ramadan Sayed K. El-Helw Eman A. E. Sallam Hanan A.
author_sort	Ramadan Sayed K.
title	Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
title_short	Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
title_full	Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
title_fullStr	Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
title_full_unstemmed	Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
title_sort	cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1h-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
publisher	De Gruyter
series	Heterocyclic Communications
issn	2191-0197
publishDate	2019-11-01
description	A pyrimidinethione derivative namely, 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile, was readily synthesized and reacted with carbon electrophiles in an attempt to synthesize selected fused heterocycles. The reactivity of 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile was investigated towards selected nitrogen nucleophiles. Thiation and hydrolysis reactions of the tetrahydropyrimidine derivative were investigated. Antitumor and antimicrobial activity evaluation of some of the synthesized products exhibited promising results.
topic	antitumor and antimicrobial activity carbon electrophiles tetrahydropyrimidine thiation thiazolopyrimidine
url	https://doi.org/10.1515/hc-2019-0008
work_keys_str_mv	AT ramadansayedk cytotoxicandantimicrobialactivitiesofsomenovelheterocyclesemploying613diphenyl1hpyrazol4yl4oxo2thioxo1234tetrahydropyrimidine5carbonitrile AT elhelwemanae cytotoxicandantimicrobialactivitiesofsomenovelheterocyclesemploying613diphenyl1hpyrazol4yl4oxo2thioxo1234tetrahydropyrimidine5carbonitrile AT sallamhanana cytotoxicandantimicrobialactivitiesofsomenovelheterocyclesemploying613diphenyl1hpyrazol4yl4oxo2thioxo1234tetrahydropyrimidine5carbonitrile
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Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

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