<i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and Treatment

• Main Authors: Nicholas Fanselow, Nadia Sirajuddin, Xiao-Tang Yin, Andrew J. W. Huang, Patrick M. Stuart
• Format: Article
• Language: English
• Published: MDPI AG 2021-03-01
• Series: Pathogens
• Subjects: <i>Acanthamoeba</i>; keratitis; pathogenesis; diagnosis; therapy
• Online Access: https://www.mdpi.com/2076-0817/10/3/323

<i>Acanthamoeba </i>keratitis is an unusual corneal infection that is recently increasing in frequency and is often contracted by contact lens wearers, someone who experienced recent eye trauma, or someone exposed to contaminated waters. <i>Acanthamoeba</i> survive in air, soil, dust, and water. Therefore, eye trauma and poor contact lens hygiene practices lead to the entrapment of debris and thus infection. <i>Acanthamoeba </i>keratitis results in severe eye pain, inflammation, and defects of the epithelium and stroma that can potentially result in vision loss if not diagnosed early and treated promptly. The disease can be diagnosed using corneal scrape/biopsy, polymerase chain reactions, impression cytology, or in vivo confocal microscopy. Once diagnosed, it is usually treated with an antimicrobial combination therapy of biguanide and aromatic diadine eye drops for several months. Advanced stages of the disease result in vision loss and the need for corneal transplants. Avoiding the risk factors and diagnosing the disease early are the most effective ways to combat <i>Acanthamoeba </i>keratitis.