<i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and Treatment
<i>Acanthamoeba </i>keratitis is an unusual corneal infection that is recently increasing in frequency and is often contracted by contact lens wearers, someone who experienced recent eye trauma, or someone exposed to contaminated waters. <i>Acanthamoeba</i> survive in air, so...
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doaj-f82aac23f8c242dea3270c4ecc80f4fd2021-03-11T00:01:53ZengMDPI AGPathogens2076-08172021-03-011032332310.3390/pathogens10030323<i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and TreatmentNicholas Fanselow0Nadia Sirajuddin1Xiao-Tang Yin2Andrew J. W. Huang3Patrick M. Stuart4Department of Ophthalmology, Saint Louis University, Saint Louis, MO 63104, USADepartment of Ophthalmology, Saint Louis University, Saint Louis, MO 63104, USADepartment of Ophthalmology, Saint Louis University, Saint Louis, MO 63104, USADepartment of Ophthalmology and Visual Sciences, Washington University, Saint Louis, MO 63110, USADepartment of Ophthalmology, Saint Louis University, Saint Louis, MO 63104, USA<i>Acanthamoeba </i>keratitis is an unusual corneal infection that is recently increasing in frequency and is often contracted by contact lens wearers, someone who experienced recent eye trauma, or someone exposed to contaminated waters. <i>Acanthamoeba</i> survive in air, soil, dust, and water. Therefore, eye trauma and poor contact lens hygiene practices lead to the entrapment of debris and thus infection. <i>Acanthamoeba </i>keratitis results in severe eye pain, inflammation, and defects of the epithelium and stroma that can potentially result in vision loss if not diagnosed early and treated promptly. The disease can be diagnosed using corneal scrape/biopsy, polymerase chain reactions, impression cytology, or in vivo confocal microscopy. Once diagnosed, it is usually treated with an antimicrobial combination therapy of biguanide and aromatic diadine eye drops for several months. Advanced stages of the disease result in vision loss and the need for corneal transplants. Avoiding the risk factors and diagnosing the disease early are the most effective ways to combat <i>Acanthamoeba </i>keratitis.https://www.mdpi.com/2076-0817/10/3/323<i>Acanthamoeba</i>keratitispathogenesisdiagnosistherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicholas Fanselow Nadia Sirajuddin Xiao-Tang Yin Andrew J. W. Huang Patrick M. Stuart |
spellingShingle |
Nicholas Fanselow Nadia Sirajuddin Xiao-Tang Yin Andrew J. W. Huang Patrick M. Stuart <i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and Treatment Pathogens <i>Acanthamoeba</i> keratitis pathogenesis diagnosis therapy |
author_facet |
Nicholas Fanselow Nadia Sirajuddin Xiao-Tang Yin Andrew J. W. Huang Patrick M. Stuart |
author_sort |
Nicholas Fanselow |
title |
<i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and Treatment |
title_short |
<i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and Treatment |
title_full |
<i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and Treatment |
title_fullStr |
<i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and Treatment |
title_full_unstemmed |
<i>Acanthamoeba</i> Keratitis, Pathology, Diagnosis and Treatment |
title_sort |
<i>acanthamoeba</i> keratitis, pathology, diagnosis and treatment |
publisher |
MDPI AG |
series |
Pathogens |
issn |
2076-0817 |
publishDate |
2021-03-01 |
description |
<i>Acanthamoeba </i>keratitis is an unusual corneal infection that is recently increasing in frequency and is often contracted by contact lens wearers, someone who experienced recent eye trauma, or someone exposed to contaminated waters. <i>Acanthamoeba</i> survive in air, soil, dust, and water. Therefore, eye trauma and poor contact lens hygiene practices lead to the entrapment of debris and thus infection. <i>Acanthamoeba </i>keratitis results in severe eye pain, inflammation, and defects of the epithelium and stroma that can potentially result in vision loss if not diagnosed early and treated promptly. The disease can be diagnosed using corneal scrape/biopsy, polymerase chain reactions, impression cytology, or in vivo confocal microscopy. Once diagnosed, it is usually treated with an antimicrobial combination therapy of biguanide and aromatic diadine eye drops for several months. Advanced stages of the disease result in vision loss and the need for corneal transplants. Avoiding the risk factors and diagnosing the disease early are the most effective ways to combat <i>Acanthamoeba </i>keratitis. |
topic |
<i>Acanthamoeba</i> keratitis pathogenesis diagnosis therapy |
url |
https://www.mdpi.com/2076-0817/10/3/323 |
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