Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia Nervosa
The etiology of pathological eating in anorexia nervosa (AN) remains poorly understood. Cerebral blood flow (CBF) is an indirect marker of neuronal function. In healthy adults, fasting increases CBF, reflecting increased delivery of oxygen and glucose to support brain metabolism. This study investig...
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doaj-f831d27087be402fa0ba177b05ddc7582020-11-24T23:00:01ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2017-07-01410.3389/fnut.2017.00032267070Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia NervosaChristina E. Wierenga0Amanda Bischoff-Grethe1Grace Rasmusson2Ursula F. Bailer3Ursula F. Bailer4Laura A. Berner5Thomas T. Liu6Walter H. Kaye7Department of Psychiatry, University of California San Diego, La Jolla, CA, United StatesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United StatesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United StatesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United StatesDivision of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AustriaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United StatesDepartment of Radiology, University of California San Diego, La Jolla, CA, United StatesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United StatesThe etiology of pathological eating in anorexia nervosa (AN) remains poorly understood. Cerebral blood flow (CBF) is an indirect marker of neuronal function. In healthy adults, fasting increases CBF, reflecting increased delivery of oxygen and glucose to support brain metabolism. This study investigated whether women remitted from restricting-type AN (RAN) have altered CBF in response to hunger that may indicate homeostatic dysregulation contributing to their ability to restrict food. We compared resting CBF measured with pulsed arterial spin labeling in 21 RAN and 16 healthy comparison women (CW) when hungry (after a 16-h fast) and after a meal. Only remitted subjects were examined to avoid the confounding effects of malnutrition on brain function. Compared to CW, RAN demonstrated a reduced difference in the Hungry − Fed CBF contrast in the right ventral striatum, right subgenual anterior cingulate cortex (pcorr < 0.05) and left posterior insula (punc < 0.05); RAN had decreased CBF when hungry versus fed, whereas CW had increased CBF when hungry versus fed. Moreover, decreased CBF when hungry in the left insula was associated with greater hunger ratings on the fasted day for RAN. This represents the first study to show that women remitted from AN have aberrant resting neurovascular function in homeostatic neural circuitry in response to hunger. Regions involved in homeostatic regulation showed group differences in the Hungry − Fed contrast, suggesting altered cellular energy metabolism in this circuitry that may reduce motivation to eat.http://journal.frontiersin.org/article/10.3389/fnut.2017.00032/fullanorexia nervosahungercerebral blood flowhomeostatic regulationenergy metabolismarterial spin labeling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christina E. Wierenga Amanda Bischoff-Grethe Grace Rasmusson Ursula F. Bailer Ursula F. Bailer Laura A. Berner Thomas T. Liu Walter H. Kaye |
spellingShingle |
Christina E. Wierenga Amanda Bischoff-Grethe Grace Rasmusson Ursula F. Bailer Ursula F. Bailer Laura A. Berner Thomas T. Liu Walter H. Kaye Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia Nervosa Frontiers in Nutrition anorexia nervosa hunger cerebral blood flow homeostatic regulation energy metabolism arterial spin labeling |
author_facet |
Christina E. Wierenga Amanda Bischoff-Grethe Grace Rasmusson Ursula F. Bailer Ursula F. Bailer Laura A. Berner Thomas T. Liu Walter H. Kaye |
author_sort |
Christina E. Wierenga |
title |
Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia Nervosa |
title_short |
Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia Nervosa |
title_full |
Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia Nervosa |
title_fullStr |
Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia Nervosa |
title_full_unstemmed |
Aberrant Cerebral Blood Flow in Response to Hunger and Satiety in Women Remitted from Anorexia Nervosa |
title_sort |
aberrant cerebral blood flow in response to hunger and satiety in women remitted from anorexia nervosa |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Nutrition |
issn |
2296-861X |
publishDate |
2017-07-01 |
description |
The etiology of pathological eating in anorexia nervosa (AN) remains poorly understood. Cerebral blood flow (CBF) is an indirect marker of neuronal function. In healthy adults, fasting increases CBF, reflecting increased delivery of oxygen and glucose to support brain metabolism. This study investigated whether women remitted from restricting-type AN (RAN) have altered CBF in response to hunger that may indicate homeostatic dysregulation contributing to their ability to restrict food. We compared resting CBF measured with pulsed arterial spin labeling in 21 RAN and 16 healthy comparison women (CW) when hungry (after a 16-h fast) and after a meal. Only remitted subjects were examined to avoid the confounding effects of malnutrition on brain function. Compared to CW, RAN demonstrated a reduced difference in the Hungry − Fed CBF contrast in the right ventral striatum, right subgenual anterior cingulate cortex (pcorr < 0.05) and left posterior insula (punc < 0.05); RAN had decreased CBF when hungry versus fed, whereas CW had increased CBF when hungry versus fed. Moreover, decreased CBF when hungry in the left insula was associated with greater hunger ratings on the fasted day for RAN. This represents the first study to show that women remitted from AN have aberrant resting neurovascular function in homeostatic neural circuitry in response to hunger. Regions involved in homeostatic regulation showed group differences in the Hungry − Fed contrast, suggesting altered cellular energy metabolism in this circuitry that may reduce motivation to eat. |
topic |
anorexia nervosa hunger cerebral blood flow homeostatic regulation energy metabolism arterial spin labeling |
url |
http://journal.frontiersin.org/article/10.3389/fnut.2017.00032/full |
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