FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency
Pluripotent stem cells (PSCs) isolated in vitro from embryonic stem cells (ESCs), induced PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for their two unique characteristics: the ability to give rise to all somatic lineages and the self-renewal capacity. Numerou...
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doaj-f834ffe07edf4533ad1feac250bd68992020-11-25T02:11:45ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-02-01810.3389/fcell.2020.00079508125FGF Signaling Pathway: A Key Regulator of Stem Cell PluripotencyMajid Mossahebi-Mohammadi0Meiyu Quan1Jin-San Zhang2Jin-San Zhang3Xiaokun Li4School of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research, Wenzhou Medical University, Wenzhou, ChinaSchool of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research, Wenzhou Medical University, Wenzhou, ChinaSchool of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research, Wenzhou Medical University, Wenzhou, ChinaInstitute of Life Sciences, Wenzhou University, Wenzhou, ChinaSchool of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research, Wenzhou Medical University, Wenzhou, ChinaPluripotent stem cells (PSCs) isolated in vitro from embryonic stem cells (ESCs), induced PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for their two unique characteristics: the ability to give rise to all somatic lineages and the self-renewal capacity. Numerous intrinsic signaling pathways contribute to the maintenance of the pluripotency state of stem cells by tightly controlling key transcriptional regulators of stemness including sex determining region Y box 2 (Sox-2), octamer-binding transcription factor (Oct)3/4, krueppel-like factor 4 (Klf-4), Nanog, and c-Myc. Signaling by fibroblast growth factor (FGF) is of critical importance in regulating stem cells pluripotency. The FGF family is comprised of 22 ligands that interact with four FGF receptors (FGFRs). FGF/FGFR signaling governs fundamental cellular processes such as cell survival, proliferation, migration, differentiation, embryonic development, organogenesis, tissue repair/regeneration, and metabolism. FGF signaling is mediated by the activation of RAS – mitogen-activated protein kinase (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT, Phospholipase C Gamma (PLCγ), and signal transducers and activators of transcription (STAT), which intersects and synergizes with other signaling pathways such as Wnt, retinoic acid (RA) and transforming growth factor (TGF)-β signaling. In the current review, we summarize the role of FGF signaling in the maintenance of pluripotency state of stem cells through regulation of key transcriptional factors.https://www.frontiersin.org/article/10.3389/fcell.2020.00079/fullFGFstem cellspluripotencyself-renewaltranscription factor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Majid Mossahebi-Mohammadi Meiyu Quan Jin-San Zhang Jin-San Zhang Xiaokun Li |
spellingShingle |
Majid Mossahebi-Mohammadi Meiyu Quan Jin-San Zhang Jin-San Zhang Xiaokun Li FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency Frontiers in Cell and Developmental Biology FGF stem cells pluripotency self-renewal transcription factor |
author_facet |
Majid Mossahebi-Mohammadi Meiyu Quan Jin-San Zhang Jin-San Zhang Xiaokun Li |
author_sort |
Majid Mossahebi-Mohammadi |
title |
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency |
title_short |
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency |
title_full |
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency |
title_fullStr |
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency |
title_full_unstemmed |
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency |
title_sort |
fgf signaling pathway: a key regulator of stem cell pluripotency |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-02-01 |
description |
Pluripotent stem cells (PSCs) isolated in vitro from embryonic stem cells (ESCs), induced PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for their two unique characteristics: the ability to give rise to all somatic lineages and the self-renewal capacity. Numerous intrinsic signaling pathways contribute to the maintenance of the pluripotency state of stem cells by tightly controlling key transcriptional regulators of stemness including sex determining region Y box 2 (Sox-2), octamer-binding transcription factor (Oct)3/4, krueppel-like factor 4 (Klf-4), Nanog, and c-Myc. Signaling by fibroblast growth factor (FGF) is of critical importance in regulating stem cells pluripotency. The FGF family is comprised of 22 ligands that interact with four FGF receptors (FGFRs). FGF/FGFR signaling governs fundamental cellular processes such as cell survival, proliferation, migration, differentiation, embryonic development, organogenesis, tissue repair/regeneration, and metabolism. FGF signaling is mediated by the activation of RAS – mitogen-activated protein kinase (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT, Phospholipase C Gamma (PLCγ), and signal transducers and activators of transcription (STAT), which intersects and synergizes with other signaling pathways such as Wnt, retinoic acid (RA) and transforming growth factor (TGF)-β signaling. In the current review, we summarize the role of FGF signaling in the maintenance of pluripotency state of stem cells through regulation of key transcriptional factors. |
topic |
FGF stem cells pluripotency self-renewal transcription factor |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00079/full |
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