A meta-analysis of gene expression signatures of blood pressure and hypertension.
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP varia...
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doaj-f8560d082fc3446faee8ddcbcfa995fc2020-11-24T21:51:08ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042015-03-01113e100503510.1371/journal.pgen.1005035A meta-analysis of gene expression signatures of blood pressure and hypertension.Tianxiao HuanTõnu EskoMarjolein J PetersLuke C PillingKatharina SchrammClaudia SchurmannBrian H ChenChunyu LiuRoby JoehanesAndrew D JohnsonChen YaoSai-Xia YingPaul CourchesneLili MilaniNalini RaghavachariRichard WangPoching LiuEva ReinmaaAbbas DehghanAlbert HofmanAndré G UitterlindenDena G HernandezStefania BandinelliAndrew SingletonDavid MelzerAndres MetspaluMaren CarstensenHarald GrallertChristian HerderThomas MeitingerAnnette PetersMichael RodenMelanie WaldenbergerMarcus DörrStephan B FelixTanja ZellerInternational Consortium for Blood Pressure GWAS (ICBP)Ramachandran VasanChristopher J O'DonnellPeter J MunsonXia YangHolger ProkischUwe VölkerJoyce B J van MeursLuigi FerrucciDaniel LevyGenome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%-9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension.http://europepmc.org/articles/PMC4365001?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tianxiao Huan Tõnu Esko Marjolein J Peters Luke C Pilling Katharina Schramm Claudia Schurmann Brian H Chen Chunyu Liu Roby Joehanes Andrew D Johnson Chen Yao Sai-Xia Ying Paul Courchesne Lili Milani Nalini Raghavachari Richard Wang Poching Liu Eva Reinmaa Abbas Dehghan Albert Hofman André G Uitterlinden Dena G Hernandez Stefania Bandinelli Andrew Singleton David Melzer Andres Metspalu Maren Carstensen Harald Grallert Christian Herder Thomas Meitinger Annette Peters Michael Roden Melanie Waldenberger Marcus Dörr Stephan B Felix Tanja Zeller International Consortium for Blood Pressure GWAS (ICBP) Ramachandran Vasan Christopher J O'Donnell Peter J Munson Xia Yang Holger Prokisch Uwe Völker Joyce B J van Meurs Luigi Ferrucci Daniel Levy |
spellingShingle |
Tianxiao Huan Tõnu Esko Marjolein J Peters Luke C Pilling Katharina Schramm Claudia Schurmann Brian H Chen Chunyu Liu Roby Joehanes Andrew D Johnson Chen Yao Sai-Xia Ying Paul Courchesne Lili Milani Nalini Raghavachari Richard Wang Poching Liu Eva Reinmaa Abbas Dehghan Albert Hofman André G Uitterlinden Dena G Hernandez Stefania Bandinelli Andrew Singleton David Melzer Andres Metspalu Maren Carstensen Harald Grallert Christian Herder Thomas Meitinger Annette Peters Michael Roden Melanie Waldenberger Marcus Dörr Stephan B Felix Tanja Zeller International Consortium for Blood Pressure GWAS (ICBP) Ramachandran Vasan Christopher J O'Donnell Peter J Munson Xia Yang Holger Prokisch Uwe Völker Joyce B J van Meurs Luigi Ferrucci Daniel Levy A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Genetics |
author_facet |
Tianxiao Huan Tõnu Esko Marjolein J Peters Luke C Pilling Katharina Schramm Claudia Schurmann Brian H Chen Chunyu Liu Roby Joehanes Andrew D Johnson Chen Yao Sai-Xia Ying Paul Courchesne Lili Milani Nalini Raghavachari Richard Wang Poching Liu Eva Reinmaa Abbas Dehghan Albert Hofman André G Uitterlinden Dena G Hernandez Stefania Bandinelli Andrew Singleton David Melzer Andres Metspalu Maren Carstensen Harald Grallert Christian Herder Thomas Meitinger Annette Peters Michael Roden Melanie Waldenberger Marcus Dörr Stephan B Felix Tanja Zeller International Consortium for Blood Pressure GWAS (ICBP) Ramachandran Vasan Christopher J O'Donnell Peter J Munson Xia Yang Holger Prokisch Uwe Völker Joyce B J van Meurs Luigi Ferrucci Daniel Levy |
author_sort |
Tianxiao Huan |
title |
A meta-analysis of gene expression signatures of blood pressure and hypertension. |
title_short |
A meta-analysis of gene expression signatures of blood pressure and hypertension. |
title_full |
A meta-analysis of gene expression signatures of blood pressure and hypertension. |
title_fullStr |
A meta-analysis of gene expression signatures of blood pressure and hypertension. |
title_full_unstemmed |
A meta-analysis of gene expression signatures of blood pressure and hypertension. |
title_sort |
meta-analysis of gene expression signatures of blood pressure and hypertension. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Genetics |
issn |
1553-7390 1553-7404 |
publishDate |
2015-03-01 |
description |
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%-9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension. |
url |
http://europepmc.org/articles/PMC4365001?pdf=render |
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