Role of endoplasmic reticulum stress-mediated apoptosis in liver fibrosis

• Main Authors: ZHANG Xu, WANG Yu, MA Juan
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2015-09-01
• Series: Linchuang Gandanbing Zazhi
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=6774

Recent studies have found that endoplasmic reticulum stress (ERS) is a common feature of the pathogenesis of organ fibrosis. However, the functional alteration of ERS and its potential role in the process of liver fibrosis is still unclear. This review summarizes the potential function of ERS and ERS-mediated apoptosis in liver fibrosis, suggesting that ERS is a cellular self-protection mechanism, but excessive ERS could cause irreversible cell damage and even induce apoptosis. However, the mechanism of ERS-mediated apoptosis involved in liver fibrosis has not been well understood and merits further exploration. With the further thorough research on the association between liver diseases and ERS, the treatments for liver diseases will be more apposite in the future.