Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal Function
There have been good amounts of population pharmacokinetics (PPK) models of vancomycin for Chinese pediatric patients, but none of them had a special focus on modeling infant population with different levels of renal function. Since renal function variability is prominent among infant population and...
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doaj-f86f5d18232d495eb676ff16c6b973f52021-09-20T14:13:54ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-09-01910.3389/fped.2021.713588713588Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal FunctionDe-Yi Li0Ling Li1Ling Li2Gui-Zhou Li3Gui-Zhou Li4Ya-Hui Hu5Hong-Li Guo6Xia Jing7Feng Chen8Xing Ji9Jing Xu10Hao-Ran Dai11Hao-Ran Dai12Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaPharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaThere have been good amounts of population pharmacokinetics (PPK) models of vancomycin for Chinese pediatric patients, but none of them had a special focus on modeling infant population with different levels of renal function. Since renal function variability is prominent among infant population and the clearance (CL) of vancomycin is heavily related to renal excretion, it is important to establish precise PPK models based on individual renal function levels. We employed a PPK approach to develop three models of vancomycin in parallel for Chinese pediatric patients with normal renal function [estimated glomerular filtration rate (eGFR) between 30 and 86 ml/min/1.73 m2, Model 1], with augmented renal function (eGFR ≥ 86 ml/min/1.73 m2, Model 2), or with all levels of renal function (Model 3). Three one-compartment models with first-order elimination kinetics were established. The predictive ability of Model 1 and Model 2 among each certain population is comparable with that of Model 3 with no statistical difference. Our study revealed that among the infant population with augmented renal function, only body weight was included as a covariate, which indicated that for an infant whose eGFR ≥ 86 ml/min/1.73 m2, taking blood sample is not compulsory for predicting vancomycin blood concentration, which avoids unnecessary injury to vulnerable infants.https://www.frontiersin.org/articles/10.3389/fped.2021.713588/fullvancomycinpediatricspopulation pharmacokineticsrenal functionexternal validation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
De-Yi Li Ling Li Ling Li Gui-Zhou Li Gui-Zhou Li Ya-Hui Hu Hong-Li Guo Xia Jing Feng Chen Xing Ji Jing Xu Hao-Ran Dai Hao-Ran Dai |
spellingShingle |
De-Yi Li Ling Li Ling Li Gui-Zhou Li Gui-Zhou Li Ya-Hui Hu Hong-Li Guo Xia Jing Feng Chen Xing Ji Jing Xu Hao-Ran Dai Hao-Ran Dai Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal Function Frontiers in Pediatrics vancomycin pediatrics population pharmacokinetics renal function external validation |
author_facet |
De-Yi Li Ling Li Ling Li Gui-Zhou Li Gui-Zhou Li Ya-Hui Hu Hong-Li Guo Xia Jing Feng Chen Xing Ji Jing Xu Hao-Ran Dai Hao-Ran Dai |
author_sort |
De-Yi Li |
title |
Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal Function |
title_short |
Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal Function |
title_full |
Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal Function |
title_fullStr |
Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal Function |
title_full_unstemmed |
Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal Function |
title_sort |
population pharmacokinetics modeling of vancomycin among chinese infants with normal and augmented renal function |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2021-09-01 |
description |
There have been good amounts of population pharmacokinetics (PPK) models of vancomycin for Chinese pediatric patients, but none of them had a special focus on modeling infant population with different levels of renal function. Since renal function variability is prominent among infant population and the clearance (CL) of vancomycin is heavily related to renal excretion, it is important to establish precise PPK models based on individual renal function levels. We employed a PPK approach to develop three models of vancomycin in parallel for Chinese pediatric patients with normal renal function [estimated glomerular filtration rate (eGFR) between 30 and 86 ml/min/1.73 m2, Model 1], with augmented renal function (eGFR ≥ 86 ml/min/1.73 m2, Model 2), or with all levels of renal function (Model 3). Three one-compartment models with first-order elimination kinetics were established. The predictive ability of Model 1 and Model 2 among each certain population is comparable with that of Model 3 with no statistical difference. Our study revealed that among the infant population with augmented renal function, only body weight was included as a covariate, which indicated that for an infant whose eGFR ≥ 86 ml/min/1.73 m2, taking blood sample is not compulsory for predicting vancomycin blood concentration, which avoids unnecessary injury to vulnerable infants. |
topic |
vancomycin pediatrics population pharmacokinetics renal function external validation |
url |
https://www.frontiersin.org/articles/10.3389/fped.2021.713588/full |
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