Autophagy in HCV Replication and Protein Trafficking

Autophagy in HCV Replication and Protein Trafficking

Autophagy is a catabolic process that is important for maintaining cellular homeostasis. It is also known to possess other functions including protein trafficking and anti-microbial activities. Hepatitis C virus (HCV) is known to co-opt cellular autophagy pathway to promote its own replication. HCV...

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Main Authors: Ja Yeon Kim Chu, Jing-hsiung James Ou
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis C virus
autophagy
mitophagy
autophagosome biogenesis
HCV RNA replication
innate immunity
Online Access:https://www.mdpi.com/1422-0067/22/3/1089
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spelling doaj-f8731937e82d4aaf9e411e347b7b3f0e2021-01-23T00:03:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01221089108910.3390/ijms22031089Autophagy in HCV Replication and Protein TraffickingJa Yeon Kim Chu0Jing-hsiung James Ou1Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USADepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USAAutophagy is a catabolic process that is important for maintaining cellular homeostasis. It is also known to possess other functions including protein trafficking and anti-microbial activities. Hepatitis C virus (HCV) is known to co-opt cellular autophagy pathway to promote its own replication. HCV regulates autophagy through multiple mechanisms to control intracellular protein and membrane trafficking to enhance its replication and suppress host innate immune response. In this review, we discuss the current knowledge on the interplay between HCV and autophagy and the crosstalk between HCV-induced autophagy and host innate immune responses.https://www.mdpi.com/1422-0067/22/3/1089hepatitis C virusautophagymitophagyautophagosome biogenesisHCV RNA replicationinnate immunity
collection DOAJ
language English
format Article
sources DOAJ
author Ja Yeon Kim Chu
Jing-hsiung James Ou
spellingShingle Ja Yeon Kim Chu
Jing-hsiung James Ou
Autophagy in HCV Replication and Protein Trafficking
International Journal of Molecular Sciences
hepatitis C virus
autophagy
mitophagy
autophagosome biogenesis
HCV RNA replication
innate immunity
author_facet Ja Yeon Kim Chu
Jing-hsiung James Ou
author_sort Ja Yeon Kim Chu
title Autophagy in HCV Replication and Protein Trafficking
title_short Autophagy in HCV Replication and Protein Trafficking
title_full Autophagy in HCV Replication and Protein Trafficking
title_fullStr Autophagy in HCV Replication and Protein Trafficking
title_full_unstemmed Autophagy in HCV Replication and Protein Trafficking
title_sort autophagy in hcv replication and protein trafficking
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-01-01
description Autophagy is a catabolic process that is important for maintaining cellular homeostasis. It is also known to possess other functions including protein trafficking and anti-microbial activities. Hepatitis C virus (HCV) is known to co-opt cellular autophagy pathway to promote its own replication. HCV regulates autophagy through multiple mechanisms to control intracellular protein and membrane trafficking to enhance its replication and suppress host innate immune response. In this review, we discuss the current knowledge on the interplay between HCV and autophagy and the crosstalk between HCV-induced autophagy and host innate immune responses.
topic hepatitis C virus
autophagy
mitophagy
autophagosome biogenesis
HCV RNA replication
innate immunity
url https://www.mdpi.com/1422-0067/22/3/1089
work_keys_str_mv AT jayeonkimchu autophagyinhcvreplicationandproteintrafficking
AT jinghsiungjamesou autophagyinhcvreplicationandproteintrafficking
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