Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis
Introduction. Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and is related to high mortality rates during follow-up of these individuals. We sought to evaluate the diagnostic value of C-reactive protein (CRP) and procalcitonin (PCT) in diagnosing infec...
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doaj-f87d5b28475b403bbd905c765f7c89982021-06-09T05:54:14ZengElsevierAnnals of Hepatology1665-26812013-07-01124431439Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosisCésar Lazzarotto, M.D.0Marcelo Fernando Ronsoni1Leonardo Fayad2Christiane Lourenço Nogueira3Maria Luiza Bazzo4Janaína Luz Narciso-Schiavon5Leonardo de Lucca Schiavon6Esther Buzaglo Dantas-Corrêa7Division of Gastroenterology, Federal University of Santa Catarina. Brasil; Correspondence and reprint request:Division of Gastroenterology, Federal University of Santa Catarina. BrasilDivision of Gastroenterology, Federal University of Santa Catarina. BrasilDepartment of Clinical Analysis, Federal University of Santa Catarina. BrasilDepartment of Clinical Analysis, Federal University of Santa Catarina. BrasilDivision of Gastroenterology, Federal University of Santa Catarina. BrasilDivision of Gastroenterology, Federal University of Santa Catarina. BrasilDivision of Gastroenterology, Federal University of Santa Catarina. BrasilIntroduction. Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and is related to high mortality rates during follow-up of these individuals. We sought to evaluate the diagnostic value of C-reactive protein (CRP) and procalcitonin (PCT) in diagnosing infection and to investigate the relationship between these biomarkers and mortality after hospital admission.Material and methods. Prospective study that included cirrhotic patients admitted to the hospital due to complications of the disease. The diagnostic accuracy of CRP and PCT for the diagnosis of infection was evaluated by estimating the sensitivity and specificity and by measuring the area under the receiver operating characteristics curve (AUROC).Results. A total of 64 patients and 81 hospitalizations were analyzed during the study. The mean age was 54.31 ± 11.87 years with male predominance (68.8%). Significantly higher median CRP and PCT levels were observed among infected patients (P < 0.001). The AUROC of CRP and PCT for the diagnosis of infection were 0.835 ± 0.052 and 0.860 ± 0.047, respectively (P = 0.273). CRP levels > 29.5 exhibited sensitivity of 82% and specificity of 81% for the diagnosis of bacterial infection. Similarly, PCT levels > 1.10 showed sensitivity of 67% and specificity of 90%. Significantly higher levels of CRP (P = 0.026) and PCT (P = 0.001) were observed among those who died within three months after admission.Conclusion. CRP and PCT were reliable markers of bacterial infection in subjects admitted due to complications of liver cirrhosis and higher levels of these tests are related to short-term mortality in those patients.http://www.sciencedirect.com/science/article/pii/S1665268119313444Liver diseaseProcalcitoninC-reactive proteinSurvival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
César Lazzarotto, M.D. Marcelo Fernando Ronsoni Leonardo Fayad Christiane Lourenço Nogueira Maria Luiza Bazzo Janaína Luz Narciso-Schiavon Leonardo de Lucca Schiavon Esther Buzaglo Dantas-Corrêa |
spellingShingle |
César Lazzarotto, M.D. Marcelo Fernando Ronsoni Leonardo Fayad Christiane Lourenço Nogueira Maria Luiza Bazzo Janaína Luz Narciso-Schiavon Leonardo de Lucca Schiavon Esther Buzaglo Dantas-Corrêa Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis Annals of Hepatology Liver disease Procalcitonin C-reactive protein Survival |
author_facet |
César Lazzarotto, M.D. Marcelo Fernando Ronsoni Leonardo Fayad Christiane Lourenço Nogueira Maria Luiza Bazzo Janaína Luz Narciso-Schiavon Leonardo de Lucca Schiavon Esther Buzaglo Dantas-Corrêa |
author_sort |
César Lazzarotto, M.D. |
title |
Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis |
title_short |
Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis |
title_full |
Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis |
title_fullStr |
Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis |
title_full_unstemmed |
Acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis |
title_sort |
acute phase proteins for the diagnosis of bacterial infection and prediction of mortality in acute complications of cirrhosis |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2013-07-01 |
description |
Introduction. Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and is related to high mortality rates during follow-up of these individuals. We sought to evaluate the diagnostic value of C-reactive protein (CRP) and procalcitonin (PCT) in diagnosing infection and to investigate the relationship between these biomarkers and mortality after hospital admission.Material and methods. Prospective study that included cirrhotic patients admitted to the hospital due to complications of the disease. The diagnostic accuracy of CRP and PCT for the diagnosis of infection was evaluated by estimating the sensitivity and specificity and by measuring the area under the receiver operating characteristics curve (AUROC).Results. A total of 64 patients and 81 hospitalizations were analyzed during the study. The mean age was 54.31 ± 11.87 years with male predominance (68.8%). Significantly higher median CRP and PCT levels were observed among infected patients (P < 0.001). The AUROC of CRP and PCT for the diagnosis of infection were 0.835 ± 0.052 and 0.860 ± 0.047, respectively (P = 0.273). CRP levels > 29.5 exhibited sensitivity of 82% and specificity of 81% for the diagnosis of bacterial infection. Similarly, PCT levels > 1.10 showed sensitivity of 67% and specificity of 90%. Significantly higher levels of CRP (P = 0.026) and PCT (P = 0.001) were observed among those who died within three months after admission.Conclusion. CRP and PCT were reliable markers of bacterial infection in subjects admitted due to complications of liver cirrhosis and higher levels of these tests are related to short-term mortality in those patients. |
topic |
Liver disease Procalcitonin C-reactive protein Survival |
url |
http://www.sciencedirect.com/science/article/pii/S1665268119313444 |
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