Liposomal Drug Delivery Systems and Anticancer Drugs
Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are various causes of cancer, such as smoking, being overweight or obese, intake of processed meat, radiation, family history, stress, environmental factors, and chance. The first-line treatment of cancer is th...
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doaj-f8845e0af2154b50b81669d4059801f62020-11-24T21:33:46ZengMDPI AGMolecules1420-30492018-04-0123490710.3390/molecules23040907molecules23040907Liposomal Drug Delivery Systems and Anticancer DrugsTemidayo O. B. Olusanya0Rita Rushdi Haj Ahmad1Daniel M. Ibegbu2James R. Smith3Amal Ali Elkordy4School of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UKSchool of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UKDepartment of Medical Biochemistry, College of Medicine, University of Nigeria Enugu Campus, NigeriaSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UKSchool of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UKCancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are various causes of cancer, such as smoking, being overweight or obese, intake of processed meat, radiation, family history, stress, environmental factors, and chance. The first-line treatment of cancer is the surgical removal of solid tumours, radiation therapy, and chemotherapy. The systemic administration of the free drug is considered to be the main clinical failure of chemotherapy in cancer treatment, as limited drug concentration reaches the tumour site. Most of the active pharmaceutical ingredients (APIs) used in chemotherapy are highly cytotoxic to both cancer and normal cells. Accordingly, targeting the tumour vasculatures is essential for tumour treatment. In this context, encapsulation of anti-cancer drugs within the liposomal system offers secure platforms for the targeted delivery of anti-cancer drugs for the treatment of cancer. This, in turn, can be helpful for reducing the cytotoxic side effects of anti-cancer drugs on normal cells. This short-review focuses on the use of liposomes in anti-cancer drug delivery.http://www.mdpi.com/1420-3049/23/4/907liposomesanticancer drugsdrug delivery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Temidayo O. B. Olusanya Rita Rushdi Haj Ahmad Daniel M. Ibegbu James R. Smith Amal Ali Elkordy |
spellingShingle |
Temidayo O. B. Olusanya Rita Rushdi Haj Ahmad Daniel M. Ibegbu James R. Smith Amal Ali Elkordy Liposomal Drug Delivery Systems and Anticancer Drugs Molecules liposomes anticancer drugs drug delivery |
author_facet |
Temidayo O. B. Olusanya Rita Rushdi Haj Ahmad Daniel M. Ibegbu James R. Smith Amal Ali Elkordy |
author_sort |
Temidayo O. B. Olusanya |
title |
Liposomal Drug Delivery Systems and Anticancer Drugs |
title_short |
Liposomal Drug Delivery Systems and Anticancer Drugs |
title_full |
Liposomal Drug Delivery Systems and Anticancer Drugs |
title_fullStr |
Liposomal Drug Delivery Systems and Anticancer Drugs |
title_full_unstemmed |
Liposomal Drug Delivery Systems and Anticancer Drugs |
title_sort |
liposomal drug delivery systems and anticancer drugs |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2018-04-01 |
description |
Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are various causes of cancer, such as smoking, being overweight or obese, intake of processed meat, radiation, family history, stress, environmental factors, and chance. The first-line treatment of cancer is the surgical removal of solid tumours, radiation therapy, and chemotherapy. The systemic administration of the free drug is considered to be the main clinical failure of chemotherapy in cancer treatment, as limited drug concentration reaches the tumour site. Most of the active pharmaceutical ingredients (APIs) used in chemotherapy are highly cytotoxic to both cancer and normal cells. Accordingly, targeting the tumour vasculatures is essential for tumour treatment. In this context, encapsulation of anti-cancer drugs within the liposomal system offers secure platforms for the targeted delivery of anti-cancer drugs for the treatment of cancer. This, in turn, can be helpful for reducing the cytotoxic side effects of anti-cancer drugs on normal cells. This short-review focuses on the use of liposomes in anti-cancer drug delivery. |
topic |
liposomes anticancer drugs drug delivery |
url |
http://www.mdpi.com/1420-3049/23/4/907 |
work_keys_str_mv |
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