PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
Antifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibroblast function and liver fibrosis in vivo.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12502 |
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doaj-f88a909827dd4238bbf8364f30631af22021-05-11T10:59:13ZengNature Publishing GroupNature Communications2041-17232016-08-017111110.1038/ncomms12502PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosisKatherine Martin0James Pritchett1Jessica Llewellyn2Aoibheann F. Mullan3Varinder S. Athwal4Ross Dobie5Emma Harvey6Leo Zeef7Stuart Farrow8Charles Streuli9Neil C. Henderson10Scott L. Friedman11Neil A. Hanley12Karen Piper Hanley13Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreCentre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreCentre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreCentre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreCentre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreMRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of EdinburghCentre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreBioinformatics Core Facility, Faculty of Life Sciences, University of ManchesterCentre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreWellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of ManchesterMRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of EdinburghDivision of Liver Diseases, Icahn School of Medicine at Mount SinaiCentre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreCentre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences CentreAntifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibroblast function and liver fibrosis in vivo.https://doi.org/10.1038/ncomms12502 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Katherine Martin James Pritchett Jessica Llewellyn Aoibheann F. Mullan Varinder S. Athwal Ross Dobie Emma Harvey Leo Zeef Stuart Farrow Charles Streuli Neil C. Henderson Scott L. Friedman Neil A. Hanley Karen Piper Hanley |
| spellingShingle |
Katherine Martin James Pritchett Jessica Llewellyn Aoibheann F. Mullan Varinder S. Athwal Ross Dobie Emma Harvey Leo Zeef Stuart Farrow Charles Streuli Neil C. Henderson Scott L. Friedman Neil A. Hanley Karen Piper Hanley PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis Nature Communications |
| author_facet |
Katherine Martin James Pritchett Jessica Llewellyn Aoibheann F. Mullan Varinder S. Athwal Ross Dobie Emma Harvey Leo Zeef Stuart Farrow Charles Streuli Neil C. Henderson Scott L. Friedman Neil A. Hanley Karen Piper Hanley |
| author_sort |
Katherine Martin |
| title |
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis |
| title_short |
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis |
| title_full |
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis |
| title_fullStr |
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis |
| title_full_unstemmed |
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis |
| title_sort |
pak proteins and yap-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-08-01 |
| description |
Antifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibroblast function and liver fibrosis in vivo. |
| url |
https://doi.org/10.1038/ncomms12502 |
| work_keys_str_mv |
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