Thiol redox homeostasis in neurodegenerative disease

Thiol redox homeostasis in neurodegenerative disease

This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc− cystine–glutamate exchanger and the association between p...

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Main Authors: Gethin J. McBean, Mutay Aslan, Helen R. Griffiths, Rita C. Torrão
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221323171500035X
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spelling doaj-f88f953eccbf4b0abce0a08f27373df72020-11-25T02:14:44ZengElsevierRedox Biology2213-23172015-08-015186194Thiol redox homeostasis in neurodegenerative diseaseGethin J. McBean0Mutay Aslan1Helen R. Griffiths2Rita C. Torrão3UCD School of Biomolecular and Biomedical Science, University College, Dublin, Ireland; Correspondence to: UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.Department of Medical Biochemistry, Akdeniz University School of Medicine, Antalya, TurkeySchool of Life and Health Sciences, Aston University, Birmingham, UKSchool of Life and Health Sciences, Aston University, Birmingham, UKThis review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc− cystine–glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed. Keywords: Cysteine, Glutathione, Thioredoxin, Glutaredoxin, Peroxiredoxin, Neurodegenerative diseasehttp://www.sciencedirect.com/science/article/pii/S221323171500035X
collection DOAJ
language English
format Article
sources DOAJ
author Gethin J. McBean
Mutay Aslan
Helen R. Griffiths
Rita C. Torrão
spellingShingle Gethin J. McBean
Mutay Aslan
Helen R. Griffiths
Rita C. Torrão
Thiol redox homeostasis in neurodegenerative disease
Redox Biology
author_facet Gethin J. McBean
Mutay Aslan
Helen R. Griffiths
Rita C. Torrão
author_sort Gethin J. McBean
title Thiol redox homeostasis in neurodegenerative disease
title_short Thiol redox homeostasis in neurodegenerative disease
title_full Thiol redox homeostasis in neurodegenerative disease
title_fullStr Thiol redox homeostasis in neurodegenerative disease
title_full_unstemmed Thiol redox homeostasis in neurodegenerative disease
title_sort thiol redox homeostasis in neurodegenerative disease
publisher Elsevier
series Redox Biology
issn 2213-2317
publishDate 2015-08-01
description This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc− cystine–glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed. Keywords: Cysteine, Glutathione, Thioredoxin, Glutaredoxin, Peroxiredoxin, Neurodegenerative disease
url http://www.sciencedirect.com/science/article/pii/S221323171500035X
work_keys_str_mv AT gethinjmcbean thiolredoxhomeostasisinneurodegenerativedisease
AT mutayaslan thiolredoxhomeostasisinneurodegenerativedisease
AT helenrgriffiths thiolredoxhomeostasisinneurodegenerativedisease
AT ritactorrao thiolredoxhomeostasisinneurodegenerativedisease
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