Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk of pregnancy complications, especially gestational diabetes mellitus (GDM). Me...
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Format: | Article |
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Frontiers Media S.A.
2017-09-01
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Series: | Frontiers in Endocrinology |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2017.00239/full |
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doaj-f8983f04b04f47449e758150b2006759 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nanthini Jayabalan Soumyalekshmi Nair Zarin Nuzhat Gregory E. Rice Gregory E. Rice Felipe A. Zuñiga Luis Sobrevia Luis Sobrevia Luis Sobrevia Andrea Leiva Carlos Sanhueza Jaime Agustín Gutiérrez Jaime Agustín Gutiérrez Martha Lappas Martha Lappas Dilys Jane Freeman Carlos Salomon Carlos Salomon Carlos Salomon Carlos Salomon |
spellingShingle |
Nanthini Jayabalan Soumyalekshmi Nair Zarin Nuzhat Gregory E. Rice Gregory E. Rice Felipe A. Zuñiga Luis Sobrevia Luis Sobrevia Luis Sobrevia Andrea Leiva Carlos Sanhueza Jaime Agustín Gutiérrez Jaime Agustín Gutiérrez Martha Lappas Martha Lappas Dilys Jane Freeman Carlos Salomon Carlos Salomon Carlos Salomon Carlos Salomon Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes Frontiers in Endocrinology adipose tissue extracellular vesicles adipose tissue-derived exosomes obesity gestational diabetes |
author_facet |
Nanthini Jayabalan Soumyalekshmi Nair Zarin Nuzhat Gregory E. Rice Gregory E. Rice Felipe A. Zuñiga Luis Sobrevia Luis Sobrevia Luis Sobrevia Andrea Leiva Carlos Sanhueza Jaime Agustín Gutiérrez Jaime Agustín Gutiérrez Martha Lappas Martha Lappas Dilys Jane Freeman Carlos Salomon Carlos Salomon Carlos Salomon Carlos Salomon |
author_sort |
Nanthini Jayabalan |
title |
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes |
title_short |
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes |
title_full |
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes |
title_fullStr |
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes |
title_full_unstemmed |
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes |
title_sort |
cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2017-09-01 |
description |
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk of pregnancy complications, especially gestational diabetes mellitus (GDM). Metabolism is a vital process for energy production and the maintenance of essential cellular functions. Excess energy storage is predominantly regulated by the adipose tissue. Primarily made up of adipocytes, adipose tissue acts as the body’s major energy reservoir. The role of adipose tissue, however, is not restricted to a “bag of fat.” The adipose tissue is an endocrine organ, secreting various adipokines, enzymes, growth factors, and hormones that take part in glucose and lipid metabolism. In obesity, the greater portion of the adipose tissue comprises fat, and there is increased pro-inflammatory cytokine secretion, macrophage infiltration, and reduced insulin sensitivity. Obesity contributes to systemic IR and its associated metabolic complications. Similar to adipose tissue, the placenta is also an endocrine organ. During pregnancy, the placenta secretes various molecules to maintain pregnancy physiology. In addition, the placenta plays an important role in metabolism and exchange of nutrients between mother and fetus. Inflammation at the placenta may contribute to the severity of maternal IR and her likelihood of developing GDM and may also mediate the adverse consequences of obesity and GDM on the fetus. Interestingly, studies on maternal insulin sensitivity and secretion of placental hormones have not shown a positive correlation between these phenomena. Recently, a great interest in the field of extracellular vesicles (EVs) has been observed in the literature. EVs are produced by a wide range of cells and are present in all biological fluids. EVs are involved in cell-to-cell communication. Recent evidence points to an association between adipose tissue-derived EVs and metabolic syndrome in obesity. In this review, we will discuss the changes in human placenta and adipose tissue in GDM and obesity and summarize the findings regarding the role of adipose tissue and placenta-derived EVs, with an emphasis on exosomes in obesity, and the contribution of obesity to the development of GDM. |
topic |
adipose tissue extracellular vesicles adipose tissue-derived exosomes obesity gestational diabetes |
url |
http://journal.frontiersin.org/article/10.3389/fendo.2017.00239/full |
work_keys_str_mv |
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doaj-f8983f04b04f47449e758150b20067592020-11-25T00:15:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922017-09-01810.3389/fendo.2017.00239284547Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via ExosomesNanthini Jayabalan0Soumyalekshmi Nair1Zarin Nuzhat2Gregory E. Rice3Gregory E. Rice4Felipe A. Zuñiga5Luis Sobrevia6Luis Sobrevia7Luis Sobrevia8Andrea Leiva9Carlos Sanhueza10Jaime Agustín Gutiérrez11Jaime Agustín Gutiérrez12Martha Lappas13Martha Lappas14Dilys Jane Freeman15Carlos Salomon16Carlos Salomon17Carlos Salomon18Carlos Salomon19Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, QLD, AustraliaExosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, QLD, AustraliaExosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, QLD, AustraliaExosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, QLD, AustraliaMaternal-Fetal Medicine, Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, LA, United StatesFaculty of Pharmacy, Department of Clinical Biochemistry and Immunology, University of Concepción, Concepción, ChileCellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, Faculty of Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileUniversity of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, QLD, AustraliaFaculty of Pharmacy, Department of Physiology, Universidad de Sevilla, Seville, SpainCellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, Faculty of Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileCellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, Faculty of Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileCellular Signaling and Differentiation Laboratory (CSDL), Medical Technology School, Health Sciences Faculty, Universidad San Sebastian, Santiago, ChileCellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, Faculty of Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileObstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, AustraliaMercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, VIC, Australia0Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United KingdomExosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, QLD, AustraliaMaternal-Fetal Medicine, Department of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, LA, United StatesFaculty of Pharmacy, Department of Clinical Biochemistry and Immunology, University of Concepción, Concepción, Chile1Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD, AustraliaObesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk of pregnancy complications, especially gestational diabetes mellitus (GDM). Metabolism is a vital process for energy production and the maintenance of essential cellular functions. Excess energy storage is predominantly regulated by the adipose tissue. Primarily made up of adipocytes, adipose tissue acts as the body’s major energy reservoir. The role of adipose tissue, however, is not restricted to a “bag of fat.” The adipose tissue is an endocrine organ, secreting various adipokines, enzymes, growth factors, and hormones that take part in glucose and lipid metabolism. In obesity, the greater portion of the adipose tissue comprises fat, and there is increased pro-inflammatory cytokine secretion, macrophage infiltration, and reduced insulin sensitivity. Obesity contributes to systemic IR and its associated metabolic complications. Similar to adipose tissue, the placenta is also an endocrine organ. During pregnancy, the placenta secretes various molecules to maintain pregnancy physiology. In addition, the placenta plays an important role in metabolism and exchange of nutrients between mother and fetus. Inflammation at the placenta may contribute to the severity of maternal IR and her likelihood of developing GDM and may also mediate the adverse consequences of obesity and GDM on the fetus. Interestingly, studies on maternal insulin sensitivity and secretion of placental hormones have not shown a positive correlation between these phenomena. Recently, a great interest in the field of extracellular vesicles (EVs) has been observed in the literature. EVs are produced by a wide range of cells and are present in all biological fluids. EVs are involved in cell-to-cell communication. Recent evidence points to an association between adipose tissue-derived EVs and metabolic syndrome in obesity. In this review, we will discuss the changes in human placenta and adipose tissue in GDM and obesity and summarize the findings regarding the role of adipose tissue and placenta-derived EVs, with an emphasis on exosomes in obesity, and the contribution of obesity to the development of GDM.http://journal.frontiersin.org/article/10.3389/fendo.2017.00239/fulladipose tissueextracellular vesiclesadipose tissue-derived exosomesobesitygestational diabetes |