The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors
The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01686-y |
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doaj-f89aab30d6554471bcccc005f3a1f7b02021-05-11T07:35:43ZengNature Publishing GroupNature Communications2041-17232017-11-018112010.1038/s41467-017-01686-yThe role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumorsKevin Boyé0Nadège Pujol1Isabel D Alves2Ya-Ping Chen3Thomas Daubon4Yi-Zong Lee5Stephane Dedieu6Marion Constantin7Lorenzo Bello8Marco Rossi9Rolf Bjerkvig10Shih-Che Sue11Andreas Bikfalvi12Clotilde Billottet13INSERM U1029INSERM U1029CBMNInstitute of Bioinformatics and Structural Biology, NTHUINSERM U1029Institute of Bioinformatics and Structural Biology, NTHUCNRS UMR 7369 MEDyC, Université de Reims Champagne-ArdenneINSERM U1029Neurosurgical Oncology Unit, Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Humanitas Resarch HospitalNeurosurgical Oncology Unit, Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Humanitas Resarch HospitalK.G. Jebsen Brain Tumour Research Centre, Department of Biomedicine, University of BergenInstitute of Bioinformatics and Structural Biology, NTHUINSERM U1029INSERM U1029The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration.https://doi.org/10.1038/s41467-017-01686-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kevin Boyé Nadège Pujol Isabel D Alves Ya-Ping Chen Thomas Daubon Yi-Zong Lee Stephane Dedieu Marion Constantin Lorenzo Bello Marco Rossi Rolf Bjerkvig Shih-Che Sue Andreas Bikfalvi Clotilde Billottet |
| spellingShingle |
Kevin Boyé Nadège Pujol Isabel D Alves Ya-Ping Chen Thomas Daubon Yi-Zong Lee Stephane Dedieu Marion Constantin Lorenzo Bello Marco Rossi Rolf Bjerkvig Shih-Che Sue Andreas Bikfalvi Clotilde Billottet The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors Nature Communications |
| author_facet |
Kevin Boyé Nadège Pujol Isabel D Alves Ya-Ping Chen Thomas Daubon Yi-Zong Lee Stephane Dedieu Marion Constantin Lorenzo Bello Marco Rossi Rolf Bjerkvig Shih-Che Sue Andreas Bikfalvi Clotilde Billottet |
| author_sort |
Kevin Boyé |
| title |
The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors |
| title_short |
The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors |
| title_full |
The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors |
| title_fullStr |
The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors |
| title_full_unstemmed |
The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors |
| title_sort |
role of cxcr3/lrp1 cross-talk in the invasion of primary brain tumors |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-11-01 |
| description |
The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration. |
| url |
https://doi.org/10.1038/s41467-017-01686-y |
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