Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice

Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice

The purpose of this study was to determine whether pravastatin’s prevention of aortic atherosclerosis via attenuation of IL-6 action depends on modulation of STAT3 activity. Male apoE knockout (apoE-/-) mice fed on a diet containing 1.25% cholesterol (wt/wt) were divided into pravastatin group...

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Main Authors: Xiaoxu Zhou, Dan Li, Wei Yan, Weimin Li
Format: Article
Language:English
Published: MDPI AG 2008-11-01
Series:International Journal of Molecular Sciences
Subjects:
Pravastatin
atherosclerosis
IL-6
STAT3
SOCS3
Online Access:http://www.mdpi.com/1422-0067/9/11/2253/
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spelling doaj-f8a2ee936e7e46e6abcb9a3bcc14cbf52020-11-24T21:34:42ZengMDPI AGInternational Journal of Molecular Sciences1422-00672008-11-019112253226410.3390/ijms9112253Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout MiceXiaoxu ZhouDan LiWei YanWeimin LiThe purpose of this study was to determine whether pravastatin’s prevention of aortic atherosclerosis via attenuation of IL-6 action depends on modulation of STAT3 activity. Male apoE knockout (apoE-/-) mice fed on a diet containing 1.25% cholesterol (wt/wt) were divided into pravastatin group provided with pravastatin (80 mg kg-1 per day) and atherosclerosis group. After eight weeks, pravastatin significantly prevented atherosclerotic lesion and reduced levels of IL-6 in serum and lesion, and significantly decreased expressions of phosphorylated STAT3 (pSTAT3) and increased suppressor of cytokine signaling 3 (SOCS3) expressions in lesions. Our results suggested that pravastatin’s aortic atherosclerosis preventing action via attenuation of IL-6 action may partially depend on modulation of STAT3 activity.http://www.mdpi.com/1422-0067/9/11/2253/PravastatinatherosclerosisIL-6STAT3SOCS3
collection DOAJ
language English
format Article
sources DOAJ
author Xiaoxu Zhou
Dan Li
Wei Yan
Weimin Li
spellingShingle Xiaoxu Zhou
Dan Li
Wei Yan
Weimin Li
Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice
International Journal of Molecular Sciences
Pravastatin
atherosclerosis
IL-6
STAT3
SOCS3
author_facet Xiaoxu Zhou
Dan Li
Wei Yan
Weimin Li
author_sort Xiaoxu Zhou
title Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice
title_short Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice
title_full Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice
title_fullStr Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice
title_full_unstemmed Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice
title_sort pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (stat3) to attenuate interleukin-6 (il-6) action in apoe knockout mice
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2008-11-01
description The purpose of this study was to determine whether pravastatin’s prevention of aortic atherosclerosis via attenuation of IL-6 action depends on modulation of STAT3 activity. Male apoE knockout (apoE-/-) mice fed on a diet containing 1.25% cholesterol (wt/wt) were divided into pravastatin group provided with pravastatin (80 mg kg-1 per day) and atherosclerosis group. After eight weeks, pravastatin significantly prevented atherosclerotic lesion and reduced levels of IL-6 in serum and lesion, and significantly decreased expressions of phosphorylated STAT3 (pSTAT3) and increased suppressor of cytokine signaling 3 (SOCS3) expressions in lesions. Our results suggested that pravastatin’s aortic atherosclerosis preventing action via attenuation of IL-6 action may partially depend on modulation of STAT3 activity.
topic Pravastatin
atherosclerosis
IL-6
STAT3
SOCS3
url http://www.mdpi.com/1422-0067/9/11/2253/
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AT danli pravastatinpreventsaorticatherosclerosisviamodulationofsignaltransductionandactivationoftranscription3stat3toattenuateinterleukin6il6actioninapoeknockoutmice
AT weiyan pravastatinpreventsaorticatherosclerosisviamodulationofsignaltransductionandactivationoftranscription3stat3toattenuateinterleukin6il6actioninapoeknockoutmice
AT weiminli pravastatinpreventsaorticatherosclerosisviamodulationofsignaltransductionandactivationoftranscription3stat3toattenuateinterleukin6il6actioninapoeknockoutmice
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