Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation
Publications from clinical trials of vitamin D supplementation have increased substantially over the last 15 years. Yet, despite the growing number of randomized controlled trials, meta-analyses of these studies have drawn inconsistent conclusions. Many meta-analyses assume that vitamin D is a pharm...
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doaj-f8a7c6c06b304d438ef8ae5ef072753c2020-11-24T23:40:56ZengMDPI AGNutrients2072-66432018-05-0110556110.3390/nu10050561nu10050561Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D SupplementationRobert Scragg0School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New ZealandPublications from clinical trials of vitamin D supplementation have increased substantially over the last 15 years. Yet, despite the growing number of randomized controlled trials, meta-analyses of these studies have drawn inconsistent conclusions. Many meta-analyses assume that vitamin D is a pharmacological agent, and give scant consideration of it being a nutrient. This limits their potential to detect beneficial effects in participants with vitamin D deficiency. An increasing body of evidence from both observational studies and clinical trials supports the presence of thresholds in vitamin D status below which disease risk increases and vitamin supplementation has beneficial effects. Future supplementation trials which seek to replicate these findings should recruit sufficient numbers of participants with low vitamin D levels, and not give low-dose vitamin D to the placebo group. If the presence of vitamin D thresholds for beneficial effects is confirmed, this would strengthen the need for vitamin D fortification of foods.http://www.mdpi.com/2072-6643/10/5/561dose–responserandomized controlled trialsthresholdsvitamin D supplementation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robert Scragg |
spellingShingle |
Robert Scragg Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation Nutrients dose–response randomized controlled trials thresholds vitamin D supplementation |
author_facet |
Robert Scragg |
author_sort |
Robert Scragg |
title |
Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation |
title_short |
Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation |
title_full |
Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation |
title_fullStr |
Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation |
title_full_unstemmed |
Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation |
title_sort |
emerging evidence of thresholds for beneficial effects from vitamin d supplementation |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-05-01 |
description |
Publications from clinical trials of vitamin D supplementation have increased substantially over the last 15 years. Yet, despite the growing number of randomized controlled trials, meta-analyses of these studies have drawn inconsistent conclusions. Many meta-analyses assume that vitamin D is a pharmacological agent, and give scant consideration of it being a nutrient. This limits their potential to detect beneficial effects in participants with vitamin D deficiency. An increasing body of evidence from both observational studies and clinical trials supports the presence of thresholds in vitamin D status below which disease risk increases and vitamin supplementation has beneficial effects. Future supplementation trials which seek to replicate these findings should recruit sufficient numbers of participants with low vitamin D levels, and not give low-dose vitamin D to the placebo group. If the presence of vitamin D thresholds for beneficial effects is confirmed, this would strengthen the need for vitamin D fortification of foods. |
topic |
dose–response randomized controlled trials thresholds vitamin D supplementation |
url |
http://www.mdpi.com/2072-6643/10/5/561 |
work_keys_str_mv |
AT robertscragg emergingevidenceofthresholdsforbeneficialeffectsfromvitamindsupplementation |
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