TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma
TP53 mutations are the most occurred mutation in HNSCC which might affect the ion channel genes. We aim to investigate the ion channel gene alteration under TP53 mutation and their prognostic implication. The overall mutation status of HNSCC were explored. By screening the TP53-associated ion channe...
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doaj-f8b31bfce1254854b7b9e6ebf2657d5d2020-12-02T22:34:12ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382020-11-011910.1177/1533033820972344TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell CarcinomaJing Sun PhD0Xijiao Yu PhD1Lande Xue MD2Shu Li PhD3Jianxia Li CD4Dongdong Tong MD5Yi Du PhD6 Jing Sun and Xijiao Yu contributed equally to this work. Jing Sun and Xijiao Yu contributed equally to this work. Department of Periodontology, Jinan Stomatological Hospital, Jinan, Shandong, China Hospital of Stomatology, , Jinan, Shandong, China Department of Periodontology, Jinan Stomatological Hospital, Jinan, Shandong, China Department of Oral and Maxillofacial, School and Hospital of Stomatology, , Jinan, Shandong, China Department of Endodontics, Jinan Stomatological Hospital, Jinan, Shandong, ChinaTP53 mutations are the most occurred mutation in HNSCC which might affect the ion channel genes. We aim to investigate the ion channel gene alteration under TP53 mutation and their prognostic implication. The overall mutation status of HNSCC were explored. By screening the TP53-associated ion channel genes (TICGs), an ion channel prognostic signature (ICPS) was established through a series of machine learning algorithms. The ICPS was then evaluated and its clinical significance was explored. 82 TICGs differentially expressed between TP53WT and TP53MUT were screened. Using univariate regression analysis and LASSO regression analysis and multivariate regression analysis, an ICPS containing 7 ion channel genes was established. A series of evaluation was carried out which proved the predictive ability of ICPS. Functional analysis of ICPS revealed that cancer-related pathways were enriched in high-risk group. Next, for clinical application, a nomogram was constructed based on ICPS and other independent clinicopathological factors. TP53 mutation status strongly affects the expression of ion channel genes. The ICPM we have identified is a strong indicator for HNSCC prognosis and could help with patient stratification as well as identification of novel drug targets.https://doi.org/10.1177/1533033820972344 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Sun PhD Xijiao Yu PhD Lande Xue MD Shu Li PhD Jianxia Li CD Dongdong Tong MD Yi Du PhD |
spellingShingle |
Jing Sun PhD Xijiao Yu PhD Lande Xue MD Shu Li PhD Jianxia Li CD Dongdong Tong MD Yi Du PhD TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma Technology in Cancer Research & Treatment |
author_facet |
Jing Sun PhD Xijiao Yu PhD Lande Xue MD Shu Li PhD Jianxia Li CD Dongdong Tong MD Yi Du PhD |
author_sort |
Jing Sun PhD |
title |
TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma |
title_short |
TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma |
title_full |
TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma |
title_fullStr |
TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma |
title_full_unstemmed |
TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma |
title_sort |
tp53-associated ion channel genes serve as prognostic predictor and therapeutic targets in head and neck squamous cell carcinoma |
publisher |
SAGE Publishing |
series |
Technology in Cancer Research & Treatment |
issn |
1533-0338 |
publishDate |
2020-11-01 |
description |
TP53 mutations are the most occurred mutation in HNSCC which might affect the ion channel genes. We aim to investigate the ion channel gene alteration under TP53 mutation and their prognostic implication. The overall mutation status of HNSCC were explored. By screening the TP53-associated ion channel genes (TICGs), an ion channel prognostic signature (ICPS) was established through a series of machine learning algorithms. The ICPS was then evaluated and its clinical significance was explored. 82 TICGs differentially expressed between TP53WT and TP53MUT were screened. Using univariate regression analysis and LASSO regression analysis and multivariate regression analysis, an ICPS containing 7 ion channel genes was established. A series of evaluation was carried out which proved the predictive ability of ICPS. Functional analysis of ICPS revealed that cancer-related pathways were enriched in high-risk group. Next, for clinical application, a nomogram was constructed based on ICPS and other independent clinicopathological factors. TP53 mutation status strongly affects the expression of ion channel genes. The ICPM we have identified is a strong indicator for HNSCC prognosis and could help with patient stratification as well as identification of novel drug targets. |
url |
https://doi.org/10.1177/1533033820972344 |
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