In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy.

In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy.

<h4>Objective</h4>Soluble fms-like tyrosine kinase (sFlt)-1-e15a, a primate-specific sFlt-1-isoform most abundant in the human placenta in preeclampsia, can induce preeclampsia in mice. This study compared the effects of full-length human (h)sFlt-1-e15a with those of truncated mouse (m)s...

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Bibliographic Details
Main Authors: Gabor Szalai, Yi Xu, Roberto Romero, Tinnakorn Chaiworapongsa, Zhonghui Xu, Po Jen Chiang, Hyunyoung Ahn, Birgitta Sundell, Olesya Plazyo, Yang Jiang, Mary Olive, Bing Wang, Suzanne M Jacques, Faisal Qureshi, Adi L Tarca, Offer Erez, Zhong Dong, Zoltan Papp, Sonia S Hassan, Edgar Hernandez-Andrade, Nandor Gabor Than
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0110867

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