Antidiabetic Effect of Oleuropein from Olea europaea Leaf against Alloxan Induced Type 1 Diabetic in Rats

• Main Authors: Nadir Mustafa Qadir, Khabat Anwar Ali, Suhailah Wasman Qader
• Format: Article
• Language: English
• Published: Instituto de Tecnologia do Paraná (Tecpar) 2016-05-01
• Series: Brazilian Archives of Biology and Technology
• Subjects: Oleuropein; Type 1 Diabetic; Alloxan; Antioxidant; Blood glucose and HBA1C
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100322&lng=en&tlng=en

This study have been designed to study the effect of extracted pure oleuropein from Oleaeuropaealeaf against alloxan induced type 1 diabetic rats.Diabetic male ratwas induced by injectingsingle subcutaneous injection of 100 mg/kg b.wof alloxan.Respectively, pure oleuropein compound (5, 10, 15 and 20 mg/kg.b.w)was orally administered once per a day during a period of 40 days ofexperiment.Then, the serum blood was collected for the determination of glucose level,haematological analysis, enzymatic and non-enzymatic antioxidant. Further, pancreatic tissue was evaluated for histological examination. Oleuropein showed a significant rolein attenuating the blood glucose levels and elevation of in-vivo antioxidantafter treating diabetic rats with 5 and 10 mg/kg. b.w.The haematologicaltest did not show any significant differences. The histological sections of diabetic rats treated with 5mg/kg/ b.w ofoleuropein showed regularity in size appearance of pancreatic islet with normal distribution of islet cells.Oleuropein as a natural active compound have antioxidant activity to attenuate the effect of alloxan against diabetic disease.Therefore, it can be recommended to use oleuropein as an additive food to cure type 1 diabetic.