MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION

MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION

Immunophenotypic and morphological peculiarities of immune reactions under intranasal, peroral and subcutaneous introduction of multicomponent vaccine Immunovac VP-4 containing a group of opportunistic bacterial antigens were investigated. The investigated preparation was found to cause marked activ...

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Main Authors: O. V. Lebedinskaya, N. K. Akhmatova, M. B. Brodovsky, E. A. Ilinykh, N. B. Egorova, E. A. Kurbatova, S. V. Melekhin
Format: Article
Language:Russian
Published: Scientific Сentre for Family Health and Human Reproduction Problems 2012-05-01
Series:Acta Biomedica Scientifica
Subjects:
mucosal immunity
immunovac vp-4
immunophenotype
morphological changes
mucosal immunization
parenteral immunization
Online Access:https://www.actabiomedica.ru/jour/article/view/937
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spelling doaj-f8e3711078ce4c4da3d3cc2ea3b8939f2021-08-17T13:52:39ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)288295883MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTIONO. V. Lebedinskaya0N. K. Akhmatova1M. B. Brodovsky2E. A. Ilinykh3N. B. Egorova4E. A. Kurbatova5S. V. Melekhin6E.A. Wagner Perm State Medical AcademyI.I. Mechnikov Institute of Vaccines and Sera RAMSE.A. Wagner Perm State Medical AcademyE.A. Wagner Perm State Medical AcademyI.I. Mechnikov Institute of Vaccines and Sera RAMSI.I. Mechnikov Institute of Vaccines and Sera RAMSE.A. Wagner Perm State Medical AcademyImmunophenotypic and morphological peculiarities of immune reactions under intranasal, peroral and subcutaneous introduction of multicomponent vaccine Immunovac VP-4 containing a group of opportunistic bacterial antigens were investigated. The investigated preparation was found to cause marked activation of congenital immunity effectors both in parenteral and mucosal immunization. It is manifested in the expression of differential, costimulatory, adhesive molecules on the surface of mononuclear leukocytes in proliferation of key mucosal immunity effectors (γδТ, В1, NK cells), and changes in structure, cellular composition of immunocompetent organs both regional and distant as to the site of introduction. Currently existing data on effects and mechanisms of vaccine and immunomodulator mucosal introduction allows considering the development of mucosal mono- and associated vaccines as the priority direction in modern vaccinology.https://www.actabiomedica.ru/jour/article/view/937mucosal immunityimmunovac vp-4immunophenotypemorphological changesmucosal immunizationparenteral immunization
collection DOAJ
language Russian
format Article
sources DOAJ
author O. V. Lebedinskaya
N. K. Akhmatova
M. B. Brodovsky
E. A. Ilinykh
N. B. Egorova
E. A. Kurbatova
S. V. Melekhin
spellingShingle O. V. Lebedinskaya
N. K. Akhmatova
M. B. Brodovsky
E. A. Ilinykh
N. B. Egorova
E. A. Kurbatova
S. V. Melekhin
MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
Acta Biomedica Scientifica
mucosal immunity
immunovac vp-4
immunophenotype
morphological changes
mucosal immunization
parenteral immunization
author_facet O. V. Lebedinskaya
N. K. Akhmatova
M. B. Brodovsky
E. A. Ilinykh
N. B. Egorova
E. A. Kurbatova
S. V. Melekhin
author_sort O. V. Lebedinskaya
title MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_short MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_full MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_fullStr MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_full_unstemmed MORPHOFUNCTIONAL PECULIARITIES OF MUCOSAL IMMUNITY DEPENDING ON METHODS OF OPPORTUNISTIC MICROBIAL INTRODUCTION
title_sort morphofunctional peculiarities of mucosal immunity depending on methods of opportunistic microbial introduction
publisher Scientific Сentre for Family Health and Human Reproduction Problems
series Acta Biomedica Scientifica
issn 2541-9420
2587-9596
publishDate 2012-05-01
description Immunophenotypic and morphological peculiarities of immune reactions under intranasal, peroral and subcutaneous introduction of multicomponent vaccine Immunovac VP-4 containing a group of opportunistic bacterial antigens were investigated. The investigated preparation was found to cause marked activation of congenital immunity effectors both in parenteral and mucosal immunization. It is manifested in the expression of differential, costimulatory, adhesive molecules on the surface of mononuclear leukocytes in proliferation of key mucosal immunity effectors (γδТ, В1, NK cells), and changes in structure, cellular composition of immunocompetent organs both regional and distant as to the site of introduction. Currently existing data on effects and mechanisms of vaccine and immunomodulator mucosal introduction allows considering the development of mucosal mono- and associated vaccines as the priority direction in modern vaccinology.
topic mucosal immunity
immunovac vp-4
immunophenotype
morphological changes
mucosal immunization
parenteral immunization
url https://www.actabiomedica.ru/jour/article/view/937
work_keys_str_mv AT ovlebedinskaya morphofunctionalpeculiaritiesofmucosalimmunitydependingonmethodsofopportunisticmicrobialintroduction
AT nkakhmatova morphofunctionalpeculiaritiesofmucosalimmunitydependingonmethodsofopportunisticmicrobialintroduction
AT mbbrodovsky morphofunctionalpeculiaritiesofmucosalimmunitydependingonmethodsofopportunisticmicrobialintroduction
AT eailinykh morphofunctionalpeculiaritiesofmucosalimmunitydependingonmethodsofopportunisticmicrobialintroduction
AT nbegorova morphofunctionalpeculiaritiesofmucosalimmunitydependingonmethodsofopportunisticmicrobialintroduction
AT eakurbatova morphofunctionalpeculiaritiesofmucosalimmunitydependingonmethodsofopportunisticmicrobialintroduction
AT svmelekhin morphofunctionalpeculiaritiesofmucosalimmunitydependingonmethodsofopportunisticmicrobialintroduction
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