Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity

Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity

Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to analyse complex I in heart tissue from 8 mammalian species with a longevity rang...

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Bibliographic Details
Main Authors: Natalia Mota-Martorell, Mariona Jove, Irene Pradas, Isabel Sanchez, José Gómez, Alba Naudi, Gustavo Barja, Reinald Pamplona
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
Complex I
Droplet digital PCR
Longevity
Mammals
Mitochondria
NDUFV2 subunit
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720303281

Internet

http://www.sciencedirect.com/science/article/pii/S2213231720303281

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