PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW

• Main Authors: A. A. Yakovlev, E. S. Tarabanova, A. G. Smochilin, R. A. Gapeshin, M. V. Yakovleva
• Format: Article
• Language: Russian
• Published: Academician I.P. Pavlov First St. Petersburg State Medical University 2017-09-01
• Series: Učenye Zapiski Sankt-Peterburgskogo Gosudarstvennogo Medicinskogo Universiteta im. Akad. I.P. Pavlova
• Subjects: paraproteinemic polyneuropathy; monoclonal gammapathy of undetermined significance; paraprotein; electroneuromyography
• Online Access: https://www.sci-notes.ru/jour/article/view/424

Monoclonal gammopathy of undetermined significance represents a number of conditions, the development of which is based on functional impairment of B-lymphocytes, which results in permanent pathological secretion of a single clone of immunoglobulins or their constituent chains. One of the leading and often the only clinical manifestation of monoclonal gammopathy is peripheral neuropathy associated with paraproteinemia. The article presents a clinical case of severe peripheral neuropathy associated with monoclonal gammopathy of undetermined significance. The diagnosis was confirmed on the basis of a comprehensive diagnosis, including screening paraproteinemic proteins in serum and a single urine sample is a method of immunofixation. Polyneuropathy was treated by using intravenous human immunoglobulin, as well as non-drug methods of rehabilitation (local cryotherapy, physical therapy and stabilometry). The therapy made a positive effect in reducing the symptoms, primarily the sensory and neuropathic components and polyneuropathy.