Prevalence of Vitamin B12 Deficiency Among Pregnant Women in Samsun Province of Turkey
Purpose: Vitamin B12 deficiency in infancy can cause severe demyelinating central nervous system disorder. Most cases are exclusively breast-fed infants born to mothers with deficient vitamin B12 stores. As maternal vitamin B12 stores are the main determinant of neonatal vitamin B12 status, we aimed...
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Cukurova University
2014-08-01
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doaj-f8e9d75ff51541fc84640198598903282020-11-25T00:21:01ZengCukurova UniversityÇukurova Üniversitesi Tıp Fakültesi Dergisi0250-51502014-08-01394840847161666Prevalence of Vitamin B12 Deficiency Among Pregnant Women in Samsun Province of TurkeyEbru Yilmaz Keskin0Basar Demir1Mahir igde2Banu Gulcan Oksuz3Samsun Education and Research Hospital, Pediatric Hematology and Oncology Ondokuz Mayis University, Medical School, Department of Family Medicine Samsun Education and Research Hospital, Pediatrics Samsun Education and Research Hospital, PediatricsPurpose: Vitamin B12 deficiency in infancy can cause severe demyelinating central nervous system disorder. Most cases are exclusively breast-fed infants born to mothers with deficient vitamin B12 stores. As maternal vitamin B12 stores are the main determinant of neonatal vitamin B12 status, we aimed to determine the vitamin B12 status of pregnant women at term in our region. Materials and Methods: Serum vitamin B12, folate and plasma homocysteine concentrations in addition to routine testings were measured 1-24 hour(s) before delivery in 62 pregnant women. Besides, infants born to mothers with laboratory evidence of vitamin B12 deficiency were referred to pediatric hematology unit for evaluation. Results: Thirty-six (58.1%) women had a low serum vitamin B12 level (<200 pg/ml). The mean plasma homocysteine was found as 6.82 +/- 2.38 and micro;mol/L. Among the 36 neonates whose mothers had a low serum vitamin B12 before delivery, 20 were admitted for examination. Plasma hcy level was not available in four infants. In the remaining 16, 13 (81.3%) had both a decreased vitamin B12 level (<259 pg/ml), and an elevated homocysteine concentration (>9.99 and micro;mol/L). All of the 20 infants examined had normal neurodevelopmental findings. Vitamin B12 supplementation resulted in normalization of vitamin B12 and homocysteine levels in all the cases. Conclusion: The frequency of neonatal vitamin B12 deficiency secondary to maternal deficiency may be higher than thought in Samsun province of Turkey. Large-scale screening studies may reveal its prevalence more accurately, and may help in taking preventive measurements. [Cukurova Med J 2014; 39(4.000): 840-847]http://www.scopemed.org/fulltextpdf.php?mno=161666Key Words: neonatalvitamin B12homocysteinepregnancymaternal |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ebru Yilmaz Keskin Basar Demir Mahir igde Banu Gulcan Oksuz |
spellingShingle |
Ebru Yilmaz Keskin Basar Demir Mahir igde Banu Gulcan Oksuz Prevalence of Vitamin B12 Deficiency Among Pregnant Women in Samsun Province of Turkey Çukurova Üniversitesi Tıp Fakültesi Dergisi Key Words: neonatal vitamin B12 homocysteine pregnancy maternal |
author_facet |
Ebru Yilmaz Keskin Basar Demir Mahir igde Banu Gulcan Oksuz |
author_sort |
Ebru Yilmaz Keskin |
title |
Prevalence of Vitamin B12 Deficiency Among Pregnant Women in Samsun Province of Turkey |
title_short |
Prevalence of Vitamin B12 Deficiency Among Pregnant Women in Samsun Province of Turkey |
title_full |
Prevalence of Vitamin B12 Deficiency Among Pregnant Women in Samsun Province of Turkey |
title_fullStr |
Prevalence of Vitamin B12 Deficiency Among Pregnant Women in Samsun Province of Turkey |
title_full_unstemmed |
Prevalence of Vitamin B12 Deficiency Among Pregnant Women in Samsun Province of Turkey |
title_sort |
prevalence of vitamin b12 deficiency among pregnant women in samsun province of turkey |
publisher |
Cukurova University |
series |
Çukurova Üniversitesi Tıp Fakültesi Dergisi |
issn |
0250-5150 |
publishDate |
2014-08-01 |
description |
Purpose: Vitamin B12 deficiency in infancy can cause severe demyelinating central nervous system disorder. Most cases are exclusively breast-fed infants born to mothers with deficient vitamin B12 stores. As maternal vitamin B12 stores are the main determinant of neonatal vitamin B12 status, we aimed to determine the vitamin B12 status of pregnant women at term in our region.
Materials and Methods: Serum vitamin B12, folate and plasma homocysteine concentrations in addition to routine testings were measured 1-24 hour(s) before delivery in 62 pregnant women. Besides, infants born to mothers with laboratory evidence of vitamin B12 deficiency were referred to pediatric hematology unit for evaluation.
Results: Thirty-six (58.1%) women had a low serum vitamin B12 level (<200 pg/ml). The mean plasma homocysteine was found as 6.82 +/- 2.38 and micro;mol/L. Among the 36 neonates whose mothers had a low serum vitamin B12 before delivery, 20 were admitted for examination. Plasma hcy level was not available in four infants. In the remaining 16, 13 (81.3%) had both a decreased vitamin B12 level (<259 pg/ml), and an elevated homocysteine concentration (>9.99 and micro;mol/L). All of the 20 infants examined had normal neurodevelopmental findings. Vitamin B12 supplementation resulted in normalization of vitamin B12 and homocysteine levels in all the cases.
Conclusion: The frequency of neonatal vitamin B12 deficiency secondary to maternal deficiency may be higher than thought in Samsun province of Turkey. Large-scale screening studies may reveal its prevalence more accurately, and may help in taking preventive measurements. [Cukurova Med J 2014; 39(4.000): 840-847] |
topic |
Key Words: neonatal vitamin B12 homocysteine pregnancy maternal |
url |
http://www.scopemed.org/fulltextpdf.php?mno=161666 |
work_keys_str_mv |
AT ebruyilmazkeskin prevalenceofvitaminb12deficiencyamongpregnantwomeninsamsunprovinceofturkey AT basardemir prevalenceofvitaminb12deficiencyamongpregnantwomeninsamsunprovinceofturkey AT mahirigde prevalenceofvitaminb12deficiencyamongpregnantwomeninsamsunprovinceofturkey AT banugulcanoksuz prevalenceofvitaminb12deficiencyamongpregnantwomeninsamsunprovinceofturkey |
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