Calcified fibrous pseudotumor with Castleman disease
Simultaneous calcified fibrous pseudotumor (CFT) and Castleman disease (CD) is an extremely rare association. CD is an uncommon lymphoproliferative disease that can arise in various sites of the body, while CFT is a rare type of benign fibrous lesion that frequently affects children and young adult...
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doaj-f8ef8ddc1fa642bc8f68d6ad5b0816342020-11-24T22:05:25ZengUniversity of São PauloAutopsy and Case Reports2236-19602018-08-018310.4322/acr.2018.033Calcified fibrous pseudotumor with Castleman diseaseIsmail Harmankaya0Nevzat Serdar Ugras1Tamer Sekmenli2Fatih Demir3Yavuz Köksal4Selçuk University, Faculty of Medicine, Department of Pathology.Selçuk University, Faculty of Medicine, Department of Pathology.Selçuk University, Faculty of Medicine, Department of Pediatric Surgery.Selçuk University, Faculty of Medicine, Department of Pathology.Selçuk University, Faculty of Medicine, Department of Pediatric Hematology and Oncology. Simultaneous calcified fibrous pseudotumor (CFT) and Castleman disease (CD) is an extremely rare association. CD is an uncommon lymphoproliferative disease that can arise in various sites of the body, while CFT is a rare type of benign fibrous lesion that frequently affects children and young adults, occurring as solitary or multiple lesions throughout the human body. Both entities are rare and exhibit typical and diverse histomorphological features. We report the case of a 15-year-old female patient, who, at the age of 13 had a biopsy performed at an external medical center; however, after 4 months the lesion had regrown. This lesion was removed with a surgical operation; however, it regrew 2 years later and was removed a third time. The results of the latter two biopsies were the same: CFT accompanying CD. The histologic examination of the excised lymph node and the surrounding tissue showed hyalinized fibrous tissue containing dystrophic and psammomatous calcification. In this case, the hyaline vascular type of CD was found to be intertwined with a CFT, which hampered the differentiation of whether both entities emerged within the lymph node or if the CFT developed from the soft tissue and then involved the lymph node. Future studies involving larger case series will provide a more precise insight, which should serve to resolve the current uncertainty http://www.revistas.usp.br/autopsy/article/view/149961Castleman Disease; Pathology; Tumor. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ismail Harmankaya Nevzat Serdar Ugras Tamer Sekmenli Fatih Demir Yavuz Köksal |
spellingShingle |
Ismail Harmankaya Nevzat Serdar Ugras Tamer Sekmenli Fatih Demir Yavuz Köksal Calcified fibrous pseudotumor with Castleman disease Autopsy and Case Reports Castleman Disease; Pathology; Tumor. |
author_facet |
Ismail Harmankaya Nevzat Serdar Ugras Tamer Sekmenli Fatih Demir Yavuz Köksal |
author_sort |
Ismail Harmankaya |
title |
Calcified fibrous pseudotumor with Castleman disease |
title_short |
Calcified fibrous pseudotumor with Castleman disease |
title_full |
Calcified fibrous pseudotumor with Castleman disease |
title_fullStr |
Calcified fibrous pseudotumor with Castleman disease |
title_full_unstemmed |
Calcified fibrous pseudotumor with Castleman disease |
title_sort |
calcified fibrous pseudotumor with castleman disease |
publisher |
University of São Paulo |
series |
Autopsy and Case Reports |
issn |
2236-1960 |
publishDate |
2018-08-01 |
description |
Simultaneous calcified fibrous pseudotumor (CFT) and Castleman disease (CD) is an extremely rare association. CD is an uncommon lymphoproliferative disease that can arise in various sites of the body, while CFT is a rare type of benign fibrous lesion that frequently affects children and young adults, occurring as solitary or multiple lesions throughout the human body. Both entities are rare and exhibit typical and diverse histomorphological features. We report the case of a 15-year-old female patient, who, at the age of 13 had a biopsy performed at an external medical center; however, after 4 months the lesion had regrown. This lesion was removed with a surgical operation; however, it regrew 2 years later and was removed a third time. The results of the latter two biopsies were the same: CFT accompanying CD. The histologic examination of the excised lymph node and the surrounding tissue showed hyalinized fibrous tissue containing dystrophic and psammomatous calcification. In this case, the hyaline vascular type of CD was found to be intertwined with a CFT, which hampered the differentiation of whether both entities emerged within the lymph node or if the CFT developed from the soft tissue and then involved the lymph node. Future studies involving larger case series will provide a more precise insight, which should serve to resolve the current uncertainty
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topic |
Castleman Disease; Pathology; Tumor. |
url |
http://www.revistas.usp.br/autopsy/article/view/149961 |
work_keys_str_mv |
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