Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCT
Abstract To investigate the detection of peritumoral pseudocapsule (PC) using multi-detector row computed tomography (MDCT) for tumors resected by robot-assisted laparoscopic partial nephrectomy (RAPN) for T1 renal cell carcinoma (RCC). Study participants included 206 patients with clinical T1 RCC w...
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doaj-f9022ecbf1f541acacb015aced29e9492021-01-31T16:25:59ZengNature Publishing GroupScientific Reports2045-23222021-01-011111810.1038/s41598-021-81922-0Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCTMakoto Toguchi0Toshio Takagi1Yuko Ogawa2Satoru Morita3Kazuhiko Yoshida4Tsunenori Kondo5Junpei Iizuka6Hideki Ishida7Yoji Nagashima8Kazunari Tanabe9Department of Urology, Tokyo Women’s Medical UniversityDepartment of Urology, Tokyo Women’s Medical UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical UniversityDepartment of Urology, Tokyo Women’s Medical UniversityDepartment of Urology, Tokyo Women’s Medical University Medical Center EastDepartment of Urology, Tokyo Women’s Medical UniversityDepartment of Urology, Tokyo Women’s Medical UniversityDepartment of Surgical Pathology, Tokyo Women’s Medical UniversityDepartment of Urology, Tokyo Women’s Medical UniversityAbstract To investigate the detection of peritumoral pseudocapsule (PC) using multi-detector row computed tomography (MDCT) for tumors resected by robot-assisted laparoscopic partial nephrectomy (RAPN) for T1 renal cell carcinoma (RCC). Study participants included 206 patients with clinical T1 RCC who underwent RAPN between October 2017 and February 2018. Two radiologists who were blinded to the pathological findings evaluated the computed tomography (CT) images. Radiological diagnosis of a PC was defined by a combination of observations, including a low-attenuation rim between the tumor and renal cortex in the cortico-medullary phase and a high-attenuation rim at the edge of the tumor in the nephrogenic or excretory phase. A PC was detected on CT in 156/206 tumors (76%) and identified by pathology in 182/206 (88%) tumors including 153/166 (92%) clear cell RCC, 13/14 (93%) papillary RCC, and 7/16 (44%) chromophobe RCC. In the whole cohort, CT findings showed a sensitivity of 81.3% (148/182), specificity of 66.7% (16/24), and positive predictive value of 94.9% (148/156). When the data were stratified according to pathological subtypes, MDCT was observed to have a sensitivity of 86.9% (133/153) and specificity of 61.5% (8/13) in clear cell RCC, sensitivity of 38.5% (5/13) and specificity of 100% (1/1) in papillary RCC, and sensitivity of 44.4% (4/7) and specificity of 66.7% (6/9) in chromophobe RCC. A low or high-attenuation rim around the tumor in the cortico-medullary or nephrographic-to-excretory phase indicates a PC of RCC, though the accuracy is not satisfactory even with 64- or 320-detector MDCT.https://doi.org/10.1038/s41598-021-81922-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Makoto Toguchi Toshio Takagi Yuko Ogawa Satoru Morita Kazuhiko Yoshida Tsunenori Kondo Junpei Iizuka Hideki Ishida Yoji Nagashima Kazunari Tanabe |
spellingShingle |
Makoto Toguchi Toshio Takagi Yuko Ogawa Satoru Morita Kazuhiko Yoshida Tsunenori Kondo Junpei Iizuka Hideki Ishida Yoji Nagashima Kazunari Tanabe Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCT Scientific Reports |
author_facet |
Makoto Toguchi Toshio Takagi Yuko Ogawa Satoru Morita Kazuhiko Yoshida Tsunenori Kondo Junpei Iizuka Hideki Ishida Yoji Nagashima Kazunari Tanabe |
author_sort |
Makoto Toguchi |
title |
Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCT |
title_short |
Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCT |
title_full |
Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCT |
title_fullStr |
Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCT |
title_full_unstemmed |
Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCT |
title_sort |
detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced mdct |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-01-01 |
description |
Abstract To investigate the detection of peritumoral pseudocapsule (PC) using multi-detector row computed tomography (MDCT) for tumors resected by robot-assisted laparoscopic partial nephrectomy (RAPN) for T1 renal cell carcinoma (RCC). Study participants included 206 patients with clinical T1 RCC who underwent RAPN between October 2017 and February 2018. Two radiologists who were blinded to the pathological findings evaluated the computed tomography (CT) images. Radiological diagnosis of a PC was defined by a combination of observations, including a low-attenuation rim between the tumor and renal cortex in the cortico-medullary phase and a high-attenuation rim at the edge of the tumor in the nephrogenic or excretory phase. A PC was detected on CT in 156/206 tumors (76%) and identified by pathology in 182/206 (88%) tumors including 153/166 (92%) clear cell RCC, 13/14 (93%) papillary RCC, and 7/16 (44%) chromophobe RCC. In the whole cohort, CT findings showed a sensitivity of 81.3% (148/182), specificity of 66.7% (16/24), and positive predictive value of 94.9% (148/156). When the data were stratified according to pathological subtypes, MDCT was observed to have a sensitivity of 86.9% (133/153) and specificity of 61.5% (8/13) in clear cell RCC, sensitivity of 38.5% (5/13) and specificity of 100% (1/1) in papillary RCC, and sensitivity of 44.4% (4/7) and specificity of 66.7% (6/9) in chromophobe RCC. A low or high-attenuation rim around the tumor in the cortico-medullary or nephrographic-to-excretory phase indicates a PC of RCC, though the accuracy is not satisfactory even with 64- or 320-detector MDCT. |
url |
https://doi.org/10.1038/s41598-021-81922-0 |
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