GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

A single, low dose of the NMDA receptor antagonist ketamine produces rapid antidepressant actions in treatment-resistant depressed patients. Understanding the cellular mechanisms underlying this will lead to new therapies for treating major depression. NMDARs are heteromultimeric complexes formed th...

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Bibliographic Details
Main Authors: Oliver H Miller, Lingling Yang, Chih-Chieh Wang, Elizabeth A Hargroder, Yihui Zhang, Eric Delpire, Benjamin J Hall
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
depression
cortex
synapse
ketamine
electrophysiology
protein synthesis
Online Access:https://elifesciences.org/articles/03581

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