| Summary: | Introduction: Arterial stiffness is a principal pathogenetic mechanism of aortic systolic blood pressure (SBP) augmentation, left ventricular hypertrophy and sudden cardiac death. The aim of the study was to evaluate the association between parameters of pulse wave and 44-hour ambulatory blood pressure (ABP) variables in patients with end- stage renal disease.
Methods: In 68 patients with ESRD on maintenance hemodialysis (45.6% males, median age 58.3(interquartile range (IQR) 54.6; 61.6) years, dialysis duration 62.7(47.8; 77) months applanation tonometry and 44-hour ABP monitoring was performed.
Results: Carotid-femoral pulse wave velocity (PWV) < 10 vs PWV≥10m/s was revealed in 52(76.5%) of patients respectively. Patients with PWV≥10 vs < 10 m/s had higher dialysis duration (median 60; IQR 36; 84) vs 28; IQR 11; 50.5) months, p < 0.05), peripheral SBP (148.1±24,8 vs 140.7±23,6 mmHg, p < 0.05); diastolic blood pressure (DBP) (85.7±15,2 vs 83.3±12,7 mmHg, p < 0.05); 48-hour heart rate (HR) (74.7±13,0 vs 72±8,7 bpm, p < 0.05), mean day one HR (78.7±7,5 vs 72.5±9,7 bpm, p < 0.05), 48- hour DBP variability (DBPV) (78±13 vs 88±12 mmHg, p < 0.01), day two SBP variability (13.5±4,4 vs 13.1±4,1) mmHg, p < 0.05), mean day two BD variability (12±3,9 vs median 11; 11.8±3,6) mmHg, p < 0.05).
Patients with PWV≥10 vs <10 m/s had lower daytime DBPV (median 8.5; IQR 7; 9) vs IQR 10 (8; 11) mmHg, p < 0.05), day one DBPV (median 8; IQR 8; 9) vs 9 IQR 8; 10 mmHg, p < 0.01).
Conclusions: Patients with PWV≥10 m/s had higher duration of dialysis, higher values of ambulatory DBP and higher – of HR. These findings may have implications in gaining further insights into the mechanism of arterial stiffness.
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