Antimicrobial photodynamic therapy in voice rehabilitation of patients after laryngectomy

• Main Authors: S. A. Shinkarev, S. V. Boldyrev, A. P. Zagadaev, V. N. Podolsky, V. A. Borisov, Y. I. Kostyushina
• Format: Article
• Language: Russian
• Published: Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" 2021-04-01
• Series: Biomedical Photonics
• Subjects: laryngeal cancer; laryngectomy; vocal rehabilitation; voice prosthesis; photodynamic therapy
• Online Access: https://www.pdt-journal.com/jour/article/view/474

The article is devoted to the problem of voice rehabilitation of patients after laryngectomy. Modern possibilities of repairing laryngeal vocal function, methods for extending the lifetime of voice prostheses are considered. The author’s method of prevention of infection of vocal prostheses using the antimicrobial photodynamic therapy (PDT) with chlorin-type photosensitizer Radagel is presented. Performing antimicrobial PDT of vocal prostheses increased the average operating time to 11.9 months compared to the control group (6.8 months), where a monthly dose of 150 mg of fluconazole was used for prevention. The method developed by the authors makes it possible to significantly extend the lifetime of vocal prostheses, is devoid of adverse events, is well tolerated by patients.