Impact of statins on cellular respiration and de‐differentiation of myofibroblasts in human failing hearts

Impact of statins on cellular respiration and de‐differentiation of myofibroblasts in human failing hearts

Abstract Aims Fibroblast to myofibroblast trans‐differentiation with altered bioenergetics precedes cardiac fibrosis (CF). Either prevention of differentiation or promotion of de‐differentiation could mitigate CF‐related pathologies. We determined whether 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐...

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Bibliographic Details
Main Authors: Larisa Emelyanova, Amar Sra, Eric G. Schmuck, Amish N. Raval, Francis X. Downey, Arshad Jahangir, Farhan Rizvi, Gracious R. Ross
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:ESC Heart Failure
Subjects:
Statins
Cardiac fibrosis
Mitochondria
Geranylgeranyl pyrophosphate
De‐differentiation
Online Access:https://doi.org/10.1002/ehf2.12509

Internet

https://doi.org/10.1002/ehf2.12509

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