Impact of statins on cellular respiration and de‐differentiation of myofibroblasts in human failing hearts
Abstract Aims Fibroblast to myofibroblast trans‐differentiation with altered bioenergetics precedes cardiac fibrosis (CF). Either prevention of differentiation or promotion of de‐differentiation could mitigate CF‐related pathologies. We determined whether 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐...
Main Authors: | Larisa Emelyanova, Amar Sra, Eric G. Schmuck, Amish N. Raval, Francis X. Downey, Arshad Jahangir, Farhan Rizvi, Gracious R. Ross |
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Format: | Article |
Language: | English |
Published: |
Wiley
2019-10-01
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Series: | ESC Heart Failure |
Subjects: | |
Online Access: | https://doi.org/10.1002/ehf2.12509 |
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