Seasonal influenza vaccination in patients with COPD: a systematic literature review
Abstract Background Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-rel...
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doaj-f926145f41d848bd9828de0592e09cf72020-11-24T23:02:01ZengBMCBMC Pulmonary Medicine1471-24662017-05-0117111510.1186/s12890-017-0420-8Seasonal influenza vaccination in patients with COPD: a systematic literature reviewRafik Bekkat-Berkani0Tom Wilkinson1Philippe Buchy2Gael Dos Santos3Dimitris Stefanidis4Jeanne-Marie Devaster5Nadia Meyer6GSKClinical and Experimental Sciences, Faculty of Medicine, University of SouthamptonGSKBusiness & Decision Life SciencesGSKGSKGSKAbstract Background Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-related costs. Despite longstanding recommendations to vaccinate vulnerable high-risk groups against seasonal influenza, including patients with COPD, vaccination rates remain sub-optimal in this population. Methods We conducted a systematic review to summarise current evidence from randomised controlled trials (RCTs) and observational studies on the immunogenicity, safety, efficacy, and effectiveness of seasonal influenza vaccination in patients with COPD. The selection of relevant articles was based on a three-step selection procedure according to predefined inclusion and exclusion criteria. The search yielded 650 unique hits of which 48 eligible articles were screened in full-text. Results Seventeen articles describing 13 different studies were found to be pertinent to this review. Results of four RCTs and one observational study demonstrate that seasonal influenza vaccination is immunogenic in patients with COPD. Two studies assessed the occurrence of COPD exacerbations 14 days after influenza vaccination and found no evidence of an increased risk of exacerbation. Three RCTs showed no significant difference in the occurrence of systemic effects between groups receiving influenza vaccine or placebo. Six out of seven studies on vaccine efficacy or effectiveness indicated long-term benefits of seasonal influenza vaccination, such as reduced number of exacerbations, reduced hospitalisations and outpatient visits, and decreased all-cause and respiratory mortality. Conclusions Additional large and well-designed observational studies would contribute to understanding the impact of disease severity and patient characteristics on the response to influenza vaccination. Overall, the evidence supports a positive benefit-risk ratio for seasonal influenza vaccination in patients with COPD, and supports current vaccination recommendations in this population.http://link.springer.com/article/10.1186/s12890-017-0420-8InfluenzaVaccinationCOPDImmunogenicityEfficacyEffectiveness |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rafik Bekkat-Berkani Tom Wilkinson Philippe Buchy Gael Dos Santos Dimitris Stefanidis Jeanne-Marie Devaster Nadia Meyer |
spellingShingle |
Rafik Bekkat-Berkani Tom Wilkinson Philippe Buchy Gael Dos Santos Dimitris Stefanidis Jeanne-Marie Devaster Nadia Meyer Seasonal influenza vaccination in patients with COPD: a systematic literature review BMC Pulmonary Medicine Influenza Vaccination COPD Immunogenicity Efficacy Effectiveness |
author_facet |
Rafik Bekkat-Berkani Tom Wilkinson Philippe Buchy Gael Dos Santos Dimitris Stefanidis Jeanne-Marie Devaster Nadia Meyer |
author_sort |
Rafik Bekkat-Berkani |
title |
Seasonal influenza vaccination in patients with COPD: a systematic literature review |
title_short |
Seasonal influenza vaccination in patients with COPD: a systematic literature review |
title_full |
Seasonal influenza vaccination in patients with COPD: a systematic literature review |
title_fullStr |
Seasonal influenza vaccination in patients with COPD: a systematic literature review |
title_full_unstemmed |
Seasonal influenza vaccination in patients with COPD: a systematic literature review |
title_sort |
seasonal influenza vaccination in patients with copd: a systematic literature review |
publisher |
BMC |
series |
BMC Pulmonary Medicine |
issn |
1471-2466 |
publishDate |
2017-05-01 |
description |
Abstract Background Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-related costs. Despite longstanding recommendations to vaccinate vulnerable high-risk groups against seasonal influenza, including patients with COPD, vaccination rates remain sub-optimal in this population. Methods We conducted a systematic review to summarise current evidence from randomised controlled trials (RCTs) and observational studies on the immunogenicity, safety, efficacy, and effectiveness of seasonal influenza vaccination in patients with COPD. The selection of relevant articles was based on a three-step selection procedure according to predefined inclusion and exclusion criteria. The search yielded 650 unique hits of which 48 eligible articles were screened in full-text. Results Seventeen articles describing 13 different studies were found to be pertinent to this review. Results of four RCTs and one observational study demonstrate that seasonal influenza vaccination is immunogenic in patients with COPD. Two studies assessed the occurrence of COPD exacerbations 14 days after influenza vaccination and found no evidence of an increased risk of exacerbation. Three RCTs showed no significant difference in the occurrence of systemic effects between groups receiving influenza vaccine or placebo. Six out of seven studies on vaccine efficacy or effectiveness indicated long-term benefits of seasonal influenza vaccination, such as reduced number of exacerbations, reduced hospitalisations and outpatient visits, and decreased all-cause and respiratory mortality. Conclusions Additional large and well-designed observational studies would contribute to understanding the impact of disease severity and patient characteristics on the response to influenza vaccination. Overall, the evidence supports a positive benefit-risk ratio for seasonal influenza vaccination in patients with COPD, and supports current vaccination recommendations in this population. |
topic |
Influenza Vaccination COPD Immunogenicity Efficacy Effectiveness |
url |
http://link.springer.com/article/10.1186/s12890-017-0420-8 |
work_keys_str_mv |
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