CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITIS
Background. Atopic dermatitis (AD) is an actual problem of pediatrics due to its wide prevalence. The aim is to give clinical and morphological characteristic of the skin in children with AD and reveal its relationship with clinical manifestations. Material and methods. Morphological and immunohis...
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Grodno State Medical University
2018-09-01
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Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2298/2098 |
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doaj-f92cf6742c5649ddb4b9b58fea59825d2020-11-24T20:41:41ZbelGrodno State Medical University Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta2221-87852413-01092018-09-0116442843410.25298/2221-8785-2018-16-4-428-434CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITISBedin P. G.0Lialikov S. A.1Basinskiy V. A.2Marszalek Andrzej3Shtabinskaya T. T.4Aleksinskiy V. S.5Educational Institution “Grodno State Medical University”Educational Institution “Grodno State Medical University”Educational Institution «Grodno State Medical University»Medical Academy “Ludwik Rydygier”Healthcare Institution «Grodno Regional Clinical Hospital»Healthсare Institution «Grodno City Clinical Hospital No 4»Background. Atopic dermatitis (AD) is an actual problem of pediatrics due to its wide prevalence. The aim is to give clinical and morphological characteristic of the skin in children with AD and reveal its relationship with clinical manifestations. Material and methods. Morphological and immunohistochemical study of 27 biopsies of atopic and 48 biopsies of non-atopic skin was carried out. Results. Expression of IgE and CD8 in the epidermis is a favorable sign, since the intensity of itching and the area of skin lesions is less (p=0.03 in both cases). 100% of samples of the erythematous-squamous form were infiltrated with CD4+ in derma, which is more common than in other clinical forms (p=0.01). The dynamics of the SCORAD was greater in children without infiltration of CD4 cells in the epidermis (p=0.04) due to the higher initial amount of SCORAD points (p=0.02). Conclusions. Morphological and immunohistochemical markers are significantly associated with clinical features of ADhttp://journal-grsmu.by/index.php/ojs/article/view/2298/2098atopic dermatitisskinmorphologychildren |
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DOAJ |
language |
Belarusian |
format |
Article |
sources |
DOAJ |
author |
Bedin P. G. Lialikov S. A. Basinskiy V. A. Marszalek Andrzej Shtabinskaya T. T. Aleksinskiy V. S. |
spellingShingle |
Bedin P. G. Lialikov S. A. Basinskiy V. A. Marszalek Andrzej Shtabinskaya T. T. Aleksinskiy V. S. CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITIS Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta atopic dermatitis skin morphology children |
author_facet |
Bedin P. G. Lialikov S. A. Basinskiy V. A. Marszalek Andrzej Shtabinskaya T. T. Aleksinskiy V. S. |
author_sort |
Bedin P. G. |
title |
CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITIS |
title_short |
CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITIS |
title_full |
CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITIS |
title_fullStr |
CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITIS |
title_full_unstemmed |
CLINICAL AND MORPHOLOGICAL CHARACTERISTIC OF THE SKIN IN CHILDREN WITH ATOPIC DERMATITIS |
title_sort |
clinical and morphological characteristic of the skin in children with atopic dermatitis |
publisher |
Grodno State Medical University |
series |
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
issn |
2221-8785 2413-0109 |
publishDate |
2018-09-01 |
description |
Background. Atopic dermatitis (AD) is an actual problem of pediatrics due to its wide prevalence.
The aim is to give clinical and morphological characteristic of the skin in children with AD and reveal its relationship with clinical manifestations.
Material and methods. Morphological and immunohistochemical study of 27 biopsies of atopic and 48 biopsies of non-atopic skin was carried out.
Results. Expression of IgE and CD8 in the epidermis is a favorable sign, since the intensity of itching and the area of skin lesions is less (p=0.03 in both cases). 100% of samples of the erythematous-squamous form were infiltrated with CD4+ in derma, which is more common than in other clinical forms (p=0.01). The dynamics of the SCORAD was greater in children without infiltration of CD4 cells in the epidermis (p=0.04) due to the higher initial amount of SCORAD points (p=0.02).
Conclusions. Morphological and immunohistochemical markers are significantly associated with clinical features of AD |
topic |
atopic dermatitis skin morphology children |
url |
http://journal-grsmu.by/index.php/ojs/article/view/2298/2098 |
work_keys_str_mv |
AT bedinpg clinicalandmorphologicalcharacteristicoftheskininchildrenwithatopicdermatitis AT lialikovsa clinicalandmorphologicalcharacteristicoftheskininchildrenwithatopicdermatitis AT basinskiyva clinicalandmorphologicalcharacteristicoftheskininchildrenwithatopicdermatitis AT marszalekandrzej clinicalandmorphologicalcharacteristicoftheskininchildrenwithatopicdermatitis AT shtabinskayatt clinicalandmorphologicalcharacteristicoftheskininchildrenwithatopicdermatitis AT aleksinskiyvs clinicalandmorphologicalcharacteristicoftheskininchildrenwithatopicdermatitis |
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