The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla
Object: This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for quantitative brain imaging. Material and Methods: Two subjects – termed the “traveling heads” – were imaged at ten different 7 T sites with a harmonized quantitative brain MR imaging protocol. In co...
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Elsevier
2021-05-01
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Series: | NeuroImage |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921001877 |
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doaj-f93edf3e26ca4e72b5d2a39970ee20ea |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maximilian N. Voelker Oliver Kraff Steffen Goerke Frederik B. Laun Jannis Hanspach Kerrin J. Pine Philipp Ehses Moritz Zaiss Andrzej Liebert Sina Straub Korbinian Eckstein Simon Robinson Armin N. Nagel Maria R. Stefanescu Astrid Wollrab Sabrina Klix Jörg Felder Michael Hock Dario Bosch Nikolaus Weiskopf Oliver Speck Mark E. Ladd Harald H. Quick |
spellingShingle |
Maximilian N. Voelker Oliver Kraff Steffen Goerke Frederik B. Laun Jannis Hanspach Kerrin J. Pine Philipp Ehses Moritz Zaiss Andrzej Liebert Sina Straub Korbinian Eckstein Simon Robinson Armin N. Nagel Maria R. Stefanescu Astrid Wollrab Sabrina Klix Jörg Felder Michael Hock Dario Bosch Nikolaus Weiskopf Oliver Speck Mark E. Ladd Harald H. Quick The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla NeuroImage Magnetic resonance imaging Ultrahigh field Multicenter Reproducibility Quantitative imaging |
author_facet |
Maximilian N. Voelker Oliver Kraff Steffen Goerke Frederik B. Laun Jannis Hanspach Kerrin J. Pine Philipp Ehses Moritz Zaiss Andrzej Liebert Sina Straub Korbinian Eckstein Simon Robinson Armin N. Nagel Maria R. Stefanescu Astrid Wollrab Sabrina Klix Jörg Felder Michael Hock Dario Bosch Nikolaus Weiskopf Oliver Speck Mark E. Ladd Harald H. Quick |
author_sort |
Maximilian N. Voelker |
title |
The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla |
title_short |
The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla |
title_full |
The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla |
title_fullStr |
The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla |
title_full_unstemmed |
The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla |
title_sort |
traveling heads 2.0: multicenter reproducibility of quantitative imaging methods at 7 tesla |
publisher |
Elsevier |
series |
NeuroImage |
issn |
1095-9572 |
publishDate |
2021-05-01 |
description |
Object: This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for quantitative brain imaging. Material and Methods: Two subjects – termed the “traveling heads” – were imaged at ten different 7 T sites with a harmonized quantitative brain MR imaging protocol. In conjunction with the system calibration, MP2RAGE, QSM, CEST and multi-parametric mapping/relaxometry were examined. Results: Quantitative measurements with MP2RAGE showed very high reproducibility across sites and subjects, and errors were in concordance with previous results and other field strengths. QSM had high inter-site reproducibility for relevant subcortical volumes. CEST imaging revealed systematic differences between the sites, but reproducibility was comparable to results in the literature. Relaxometry had also very high agreement between sites, but due to the high sensitivity, differences caused by different applications of the B1 calibration of the two RF coil types used were observed. Conclusion: Our results show that quantitative brain imaging can be performed with high reproducibility at 7 T and with similar reliability as found at 3 T for multicenter studies of the supratentorial brain. |
topic |
Magnetic resonance imaging Ultrahigh field Multicenter Reproducibility Quantitative imaging |
url |
http://www.sciencedirect.com/science/article/pii/S1053811921001877 |
work_keys_str_mv |
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doaj-f93edf3e26ca4e72b5d2a39970ee20ea2021-04-12T04:21:39ZengElsevierNeuroImage1095-95722021-05-01232117910The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 TeslaMaximilian N. Voelker0Oliver Kraff1Steffen Goerke2Frederik B. Laun3Jannis Hanspach4Kerrin J. Pine5Philipp Ehses6Moritz Zaiss7Andrzej Liebert8Sina Straub9Korbinian Eckstein10Simon Robinson11Armin N. Nagel12Maria R. Stefanescu13Astrid Wollrab14Sabrina Klix15Jörg Felder16Michael Hock17Dario Bosch18Nikolaus Weiskopf19Oliver Speck20Mark E. Ladd21Harald H. Quick22Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany; High-Field and Hybrid MR Imaging, University Hospital Essen, University Duisburg-Essen, Essen, Germany; Corresponding author at: Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, GermanyErwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, GermanyDivision of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, GermanyInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Max Planck Institute for Biological Cybernetics, Tübingen, GermanyInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyDivision of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, GermanyHigh Field MR Center, Department for Biomedical Imaging and Image guided Therapy, Medical University of Vienna, Vienna, AustriaHigh Field MR Center, Department for Biomedical Imaging and Image guided Therapy, Medical University of Vienna, Vienna, AustriaInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, GermanyChair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Wuerzburg, GermanyOtto-von-Guericke-University Magdeburg, Magdeburg, GermanyBerlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Center for Molecular Medicine, Berlin-Buch, GermanyInstitute of Neuroscience and Medicine (INM-4), Forschungszentrum Jülich, Jülich, GermanyChair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital Wuerzburg, Wuerzburg, GermanyMax Planck Institute for Biological Cybernetics, Tübingen, GermanyDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, GermanyOtto-von-Guericke-University Magdeburg, Magdeburg, Germany; Leibniz Institute for Neurobiology, Magdeburg, GermanyErwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, GermanyErwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany; High-Field and Hybrid MR Imaging, University Hospital Essen, University Duisburg-Essen, Essen, GermanyObject: This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for quantitative brain imaging. Material and Methods: Two subjects – termed the “traveling heads” – were imaged at ten different 7 T sites with a harmonized quantitative brain MR imaging protocol. In conjunction with the system calibration, MP2RAGE, QSM, CEST and multi-parametric mapping/relaxometry were examined. Results: Quantitative measurements with MP2RAGE showed very high reproducibility across sites and subjects, and errors were in concordance with previous results and other field strengths. QSM had high inter-site reproducibility for relevant subcortical volumes. CEST imaging revealed systematic differences between the sites, but reproducibility was comparable to results in the literature. Relaxometry had also very high agreement between sites, but due to the high sensitivity, differences caused by different applications of the B1 calibration of the two RF coil types used were observed. Conclusion: Our results show that quantitative brain imaging can be performed with high reproducibility at 7 T and with similar reliability as found at 3 T for multicenter studies of the supratentorial brain.http://www.sciencedirect.com/science/article/pii/S1053811921001877Magnetic resonance imagingUltrahigh fieldMulticenterReproducibilityQuantitative imaging |