Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis
Jianglong He,1,* Xiaoquan Li,2,* Jialin Tang,3,* Tinli Jin,3 Qinghua Liao,3 Guoliang Hu31Department of Infectious Disease, the First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2Department of Pediatrics, the First Affiliated Hospital of Xi’a...
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doaj-f94333ae97f44f629b38082743722ea72020-11-25T00:19:03ZengDove Medical PressOncoTargets and Therapy1178-69302015-04-012015default72773421212Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysisHe JLi XTang JJin TLiao QHu G Jianglong He,1,* Xiaoquan Li,2,* Jialin Tang,3,* Tinli Jin,3 Qinghua Liao,3 Guoliang Hu31Department of Infectious Disease, the First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2Department of Pediatrics, the First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China; 3Department of Public Health, Center for Disease Control and Prevention, Jiangxi Province, Nanchang, People’s Republic of China*These authors contributed equally to this workBackground: The association between chemotactic chemokine ligand 5 (CCL5) -403G/A gene polymorphism and human immunodeficiency virus-1 (HIV-1) infection has been illustrated among several case-control studies, but the conclusions are still inconsistent. Here we performed a meta-analysis to estimate the association.Methods: The published studies based upon the association between CCL5 -403G/A polymorphism and HIV-1 infection were retrieved from PubMed, Embase, and China National Knowledge Infrastructure database. Quantitative synthesis, including pooled odds ratios (ORs) and 95% confidence intervals (CIs), was performed for all genetic models.Results: A total of ten studies consisting of 5,127 subjects were included for this meta-analysis. There was no association found between -403G/A polymorphism and HIV-1 infection in the overall analysis under any genetic models. Further stratified by ethnicity, our analysis showed that -403A/A polymorphism significantly decreased the susceptibility to HIV-1 infection in three models: the dominant model (AA+AG vs GG: OR =0.44, 95% CI =0.21–0.94) among Africans, the homozygous model (AA vs GG: OR =0.62, 95% CI =0.242–0.90), and the recessive model (AA vs GG+AG: OR =0.62, 95% CI =0.45–0.93) among Asians.Conclusion: We found that only Asians and Africans with CCL5 -403A/A polymorphism could be resistant to HIV-1 infection. However, further studies should be performed to evaluate this association on ethnic basis against control groups consisting of individuals who have once been exposed to HIV-1 but are seronegative.Keywords: CCL5, polymorphism, susceptibility, HIV-1, meta-analysishttp://www.dovepress.com/association-between-chemotactic-chemokine-ligand-5--403ga-polymorphism-peer-reviewed-article-OTT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
He J Li X Tang J Jin T Liao Q Hu G |
spellingShingle |
He J Li X Tang J Jin T Liao Q Hu G Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis OncoTargets and Therapy |
author_facet |
He J Li X Tang J Jin T Liao Q Hu G |
author_sort |
He J |
title |
Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis |
title_short |
Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis |
title_full |
Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis |
title_fullStr |
Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis |
title_full_unstemmed |
Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis |
title_sort |
association between chemotactic chemokine ligand 5 -403g/a polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2015-04-01 |
description |
Jianglong He,1,* Xiaoquan Li,2,* Jialin Tang,3,* Tinli Jin,3 Qinghua Liao,3 Guoliang Hu31Department of Infectious Disease, the First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2Department of Pediatrics, the First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, People’s Republic of China; 3Department of Public Health, Center for Disease Control and Prevention, Jiangxi Province, Nanchang, People’s Republic of China*These authors contributed equally to this workBackground: The association between chemotactic chemokine ligand 5 (CCL5) -403G/A gene polymorphism and human immunodeficiency virus-1 (HIV-1) infection has been illustrated among several case-control studies, but the conclusions are still inconsistent. Here we performed a meta-analysis to estimate the association.Methods: The published studies based upon the association between CCL5 -403G/A polymorphism and HIV-1 infection were retrieved from PubMed, Embase, and China National Knowledge Infrastructure database. Quantitative synthesis, including pooled odds ratios (ORs) and 95% confidence intervals (CIs), was performed for all genetic models.Results: A total of ten studies consisting of 5,127 subjects were included for this meta-analysis. There was no association found between -403G/A polymorphism and HIV-1 infection in the overall analysis under any genetic models. Further stratified by ethnicity, our analysis showed that -403A/A polymorphism significantly decreased the susceptibility to HIV-1 infection in three models: the dominant model (AA+AG vs GG: OR =0.44, 95% CI =0.21–0.94) among Africans, the homozygous model (AA vs GG: OR =0.62, 95% CI =0.242–0.90), and the recessive model (AA vs GG+AG: OR =0.62, 95% CI =0.45–0.93) among Asians.Conclusion: We found that only Asians and Africans with CCL5 -403A/A polymorphism could be resistant to HIV-1 infection. However, further studies should be performed to evaluate this association on ethnic basis against control groups consisting of individuals who have once been exposed to HIV-1 but are seronegative.Keywords: CCL5, polymorphism, susceptibility, HIV-1, meta-analysis |
url |
http://www.dovepress.com/association-between-chemotactic-chemokine-ligand-5--403ga-polymorphism-peer-reviewed-article-OTT |
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