Pathological study on the effect of vitamin D3 on sepsis experimentally induced in rats by cecal ligation and punctures
The aim of this study was to investigate the effects of the Vitamin D3 on the rats with sepsis that experimentally induced by cecal ligation and puncture. 100 Rats were divided into 5 groups, these include untreated control group, sham-operated group, CLP group and 2 treated groups pretreated daily...
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University of Mosul, College of Veterinary Medicine
2014-06-01
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doaj-f94926c3679144eeb8bbf97725c80bc72020-11-25T02:53:07ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552014-06-012814147Pathological study on the effect of vitamin D3 on sepsis experimentally induced in rats by cecal ligation and puncturesA.M. Al-Saidya 0H.Kh. Ismail1Department of Pathology and Poultry Diseases, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Pathology and Poultry Diseases, College of Veterinary Medicine, University of Mosul, Mosul, IraqThe aim of this study was to investigate the effects of the Vitamin D3 on the rats with sepsis that experimentally induced by cecal ligation and puncture. 100 Rats were divided into 5 groups, these include untreated control group, sham-operated group, CLP group and 2 treated groups pretreated daily a Subcutaneous injections of 1,25-dihydroxyvitamin D3 100 ng/kg for 3 days, then one of the pretreated groups subjected to sepsis accomplished by abdominal surgery comprising a cecal ligation and puncture. The following parameters were recorded: survival rate, hematological examinations and histopathological changes of the liver and heart were examined. It was found that vitamin D3 pretreated showed improvement in the survival rats and enhancement in the blood leukocyte count, also protect the rats from thrombocytopenia and Disseminated Intravascular Coagulation (DIC), but vitamin D3 pretreated show slight improvement in the histopathological lesions in the liver and heart due to cecal ligation and puncture sepsis. http://www.vetmedmosul.org/ijvs/media/14-1-8e.pdfPathologyVitamin D3SepsisRats |
collection |
DOAJ |
language |
Arabic |
format |
Article |
sources |
DOAJ |
author |
A.M. Al-Saidya H.Kh. Ismail |
spellingShingle |
A.M. Al-Saidya H.Kh. Ismail Pathological study on the effect of vitamin D3 on sepsis experimentally induced in rats by cecal ligation and punctures Iraqi Journal of Veterinary Sciences Pathology Vitamin D3 Sepsis Rats |
author_facet |
A.M. Al-Saidya H.Kh. Ismail |
author_sort |
A.M. Al-Saidya |
title |
Pathological study on the effect of vitamin D3 on sepsis experimentally induced in rats by cecal ligation and punctures |
title_short |
Pathological study on the effect of vitamin D3 on sepsis experimentally induced in rats by cecal ligation and punctures |
title_full |
Pathological study on the effect of vitamin D3 on sepsis experimentally induced in rats by cecal ligation and punctures |
title_fullStr |
Pathological study on the effect of vitamin D3 on sepsis experimentally induced in rats by cecal ligation and punctures |
title_full_unstemmed |
Pathological study on the effect of vitamin D3 on sepsis experimentally induced in rats by cecal ligation and punctures |
title_sort |
pathological study on the effect of vitamin d3 on sepsis experimentally induced in rats by cecal ligation and punctures |
publisher |
University of Mosul, College of Veterinary Medicine |
series |
Iraqi Journal of Veterinary Sciences |
issn |
1607-3894 2071-1255 |
publishDate |
2014-06-01 |
description |
The aim of this study was to investigate the effects of the Vitamin D3 on the rats with sepsis that experimentally induced by cecal ligation and puncture. 100 Rats were divided into 5 groups, these include untreated control group, sham-operated group, CLP group and 2 treated groups pretreated daily a Subcutaneous injections of 1,25-dihydroxyvitamin D3 100 ng/kg for 3 days, then one of the pretreated groups subjected to sepsis accomplished by abdominal surgery comprising a cecal ligation and puncture. The following parameters were recorded: survival rate, hematological examinations and histopathological changes of the liver and heart were examined. It was found that vitamin D3 pretreated showed improvement in the survival rats and enhancement in the blood leukocyte count, also protect the rats from thrombocytopenia and Disseminated Intravascular Coagulation (DIC), but vitamin D3 pretreated show slight improvement in the histopathological lesions in the liver and heart due to cecal ligation and puncture sepsis.
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topic |
Pathology Vitamin D3 Sepsis Rats |
url |
http://www.vetmedmosul.org/ijvs/media/14-1-8e.pdf |
work_keys_str_mv |
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