Optimization of the technological cycle of formation of "core — shell" structures and the study of an- timicrobial and regenerative properties of the dispersions based on the prepared structures

• Main Authors: Zayarskiy D.A., Gorokhovskiy A.V., Nechaeva O.V., Ul'yanov V.Yu., Tikhomirova E.l., Vakaraeva M.M., Schnaider D.A., Utz S.R., Arsenievich D.M.
• Format: Article
• Language: Russian
• Published: Saratov State Medical University 2016-09-01
• Series: Саратовский научно-медицинский журнал
• Subjects: dermatology; flavonoids; nanotechnology
• Online Access: http://www.ssmj.ru/system/files/2016_03-1_462-467.pdf

<p style="font-family: &quot;Times New Roman&quot;, Times, serif; font-size: 16px; margin-bottom: 0in;"><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US"><i>The aim&nbsp;</i></span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US">of the work was to create optimized composite structures on the basis of nanoscale aggregates of fla-vonoids and study of their antimicrobial and regenerative properties.&nbsp;</span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US"><i>Material and methods.&nbsp;</i></span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US">Antimicrobial activity of the resulting preparation was studied using the serial dilution method. Standard and clinical strains of Gram-positive and Gram-negative bacteria and microscopic fungi were used as experimental models. Assessment of regenerative effect of structures containing nanoaggregates flavonoids on experimental models of full thickness skin wounds was performed.&nbsp;</span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US"><i>Results.&nbsp;</i></span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US">The high antimicrobial activity of the created structures is seen against opportunistic pathogenic microorganisms including clinical isolates resistant to multiple antibiotics. Displaying the reliable increase in rate of healing of experimental full thickness skin wounds by stimulating regenerative processes.&nbsp;</span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US"><i>Conclusion.&nbsp;</i></span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US">Developed preparation containing "core&nbsp;</span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="ru-RU" xml:lang="ru-RU">—&nbsp;</span></font></font></font><font color="#000000"><font face="Arial, serif"><font style="font-size: 9pt;"><span lang="en-US" xml:lang="en-US">shell" structure stabilized by polyelectrolyte based flavonoid nanoaggregates can be considered as a potentially new type of drugs for use in cosmetology and dermatology as well as in the treatment of contaminated surgerical wounds and thermal injuries.</span></font></font></font></p>