Synthesis and Antimycobacterial Activity of 3-Phenyl-1<i>H</i>-indoles

Synthesis and Antimycobacterial Activity of 3-Phenyl-1<i>H</i>-indoles

Tuberculosis has been described as a global health crisis since the 1990s, with an estimated 1.4 million deaths in the last year. Herein, a series of 20 1<i>H</i>-indoles were synthesized and evaluated as in vitro inhibitors of <i>Mycobacterium tuberculosis</i> (Mtb) growth....

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Bibliographic Details
Main Authors: Renata Jardim Etchart, Raoní S. Rambo, Bruno Lopes Abbadi, Nathalia Sperotto, Christiano Ev Neves, Fernanda Fries Silva, Maiele Dornelles, Lovaine Duarte, Fernanda Souza Macchi, Marcia Alberton Perelló, Rogério Vescia Lourega, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
1<i>H</i>-indoles
<i>Mycobacterium tuberculosis</i>
mammalian cellular viability
genotoxicity
time-kill
pharmacodynamic model
Online Access:https://www.mdpi.com/1420-3049/26/17/5148

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