Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region
PurposeNatural history and consequences of the novel 2009 influenza A H1N1 (2009 H1N1) infection in immunocompromised pediatric patients are not yet fully understood. In this study, we investigated the clinical features and outcomes of the 2009 H1N1 infection in pediatric patients with hematological...
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doaj-f964af5eca414e75bc93a18693b9d6262020-11-24T22:16:00ZengKorean Pediatric SocietyKorean Journal of Pediatrics1738-10612092-72582011-03-0154311712210.3345/kjp.2011.54.3.1172011540304Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam regionSeok Jeong Kang0Jae Min Lee1Jeong Ok Hah2Ye Jee Shim3Kun Soo Lee4Hyun Jung Shin5Heung Sik Kim6Eun Jin Choi7So Eun Jeon8Young Tak Lim9Ji Kyeong Park10Eun Sil Park11Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea.Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea.Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea.Department of Pediatrics, College of Medicine, Kyungbook National University, Daegu, Korea.Department of Pediatrics, College of Medicine, Kyungbook National University, Daegu, Korea.Department of Pediatrics, College of Medicine, Keimyung University, Daegu, Korea.Department of Pediatrics, College of Medicine, Keimyung University, Daegu, Korea.Department of Pediatrics, College of Medicine, Daegu Catholic University, Daegu, Korea.Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea.Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea.Department of Pediatrics, College of Medicine, Inje university, Busan, Korea.Department of Pediatrics, College of Medicine, Gyeongsang National University, Jinju, Korea.PurposeNatural history and consequences of the novel 2009 influenza A H1N1 (2009 H1N1) infection in immunocompromised pediatric patients are not yet fully understood. In this study, we investigated the clinical features and outcomes of the 2009 H1N1 infection in pediatric patients with hematological and oncological diseases.MethodsWe retrospectively reviewed the medical records of 528 patients who had hematological and oncological diseases and who were treated at 7 referral centers located in the Yeungnam region. Among the 528 patients, 27 with definite diagnosis of 2009 H1N1 infection were the subjects of this study. All patients were divided into the following 3 groups: patients who were receiving chemotherapy (group 1), patients who were immunosuppressed due to a non-malignant hematological disease (group 2), and patients who were off chemotherapy and had undergone their last chemotherapy course within 2 years from the influenza A pandemic (group 3).ResultsAll 28 episodes of 2009 H1N1 infection were treated with the antiviral agent oseltamivir (Tamiflu®), and 20 episodes were treated after hospitalization. Group 1 patients had higher frequencies of lower respiratory tract infection and longer durations of fever and hospitalization as compared to those in group 2. Ultimately, all episodes resolved completely with no complications.ConclusionThese results suggest that early antiviral therapy did not influence the morbidity or mortality of pediatric patients with hematological and oncological diseases in the Yeungnam region of Korea after the 2009 H1N1 infection. However, no definite conclusions can be drawn because of the small sample size.http://kjp.or.kr/upload/pdf/kjped-54-117.pdfInfluenza A VirusH1N1 SubtypeImmunocompromised PatientsHematologic DiseasesOseltamivirChild |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seok Jeong Kang Jae Min Lee Jeong Ok Hah Ye Jee Shim Kun Soo Lee Hyun Jung Shin Heung Sik Kim Eun Jin Choi So Eun Jeon Young Tak Lim Ji Kyeong Park Eun Sil Park |
spellingShingle |
Seok Jeong Kang Jae Min Lee Jeong Ok Hah Ye Jee Shim Kun Soo Lee Hyun Jung Shin Heung Sik Kim Eun Jin Choi So Eun Jeon Young Tak Lim Ji Kyeong Park Eun Sil Park Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region Korean Journal of Pediatrics Influenza A Virus H1N1 Subtype Immunocompromised Patients Hematologic Diseases Oseltamivir Child |
author_facet |
Seok Jeong Kang Jae Min Lee Jeong Ok Hah Ye Jee Shim Kun Soo Lee Hyun Jung Shin Heung Sik Kim Eun Jin Choi So Eun Jeon Young Tak Lim Ji Kyeong Park Eun Sil Park |
author_sort |
Seok Jeong Kang |
title |
Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region |
title_short |
Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region |
title_full |
Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region |
title_fullStr |
Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region |
title_full_unstemmed |
Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region |
title_sort |
novel influenza a (h1n1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the yeungnam region |
publisher |
Korean Pediatric Society |
series |
Korean Journal of Pediatrics |
issn |
1738-1061 2092-7258 |
publishDate |
2011-03-01 |
description |
PurposeNatural history and consequences of the novel 2009 influenza A H1N1 (2009 H1N1) infection in immunocompromised pediatric patients are not yet fully understood. In this study, we investigated the clinical features and outcomes of the 2009 H1N1 infection in pediatric patients with hematological and oncological diseases.MethodsWe retrospectively reviewed the medical records of 528 patients who had hematological and oncological diseases and who were treated at 7 referral centers located in the Yeungnam region. Among the 528 patients, 27 with definite diagnosis of 2009 H1N1 infection were the subjects of this study. All patients were divided into the following 3 groups: patients who were receiving chemotherapy (group 1), patients who were immunosuppressed due to a non-malignant hematological disease (group 2), and patients who were off chemotherapy and had undergone their last chemotherapy course within 2 years from the influenza A pandemic (group 3).ResultsAll 28 episodes of 2009 H1N1 infection were treated with the antiviral agent oseltamivir (Tamiflu®), and 20 episodes were treated after hospitalization. Group 1 patients had higher frequencies of lower respiratory tract infection and longer durations of fever and hospitalization as compared to those in group 2. Ultimately, all episodes resolved completely with no complications.ConclusionThese results suggest that early antiviral therapy did not influence the morbidity or mortality of pediatric patients with hematological and oncological diseases in the Yeungnam region of Korea after the 2009 H1N1 infection. However, no definite conclusions can be drawn because of the small sample size. |
topic |
Influenza A Virus H1N1 Subtype Immunocompromised Patients Hematologic Diseases Oseltamivir Child |
url |
http://kjp.or.kr/upload/pdf/kjped-54-117.pdf |
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