Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference

Morphogenesis involves interactions of asymmetric cell populations to form complex multicellular patterns and structures comprised of distinct cell types. However, current methods to model morphogenic events lack control over cell-type co-emergence and offer little capability to selectively perturb...

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Bibliographic Details
Main Authors: Ashley RG Libby, David A Joy, Po-Lin So, Mohammad A Mandegar, Jonathon M Muncie, Federico N Mendoza-Camacho, Valerie M Weaver, Bruce R Conklin, Todd C McDevitt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
pluripotent stem cells
morphogenesis
bio-engineering
Online Access:https://elifesciences.org/articles/36045

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