Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease
Abstract Background In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL a...
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doaj-f96d09ac8ba7458d831bdc00ae2dc7952020-11-24T21:47:19ZengBMCBMC Pulmonary Medicine1471-24662017-12-011711910.1186/s12890-017-0544-xImpact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung diseaseHirofumi Kamata0Takanori Asakura1Shoji Suzuki2Ho Namkoong3Kazuma Yagi4Yohei Funatsu5Satoshi Okamori6Shunsuke Uno7Yoshifumi Uwamino8Hiroshi Fujiwara9Tomoyasu Nishimura10Makoto Ishii11Tomoko Betsuyaku12Naoki Hasegawa13Division of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineCenter for Infectious Diseases and Infection Control, Keio University School of MedicineDepartment of Laboratory Medicine, Keio University School of MedicineCenter for Infectious Diseases and Infection Control, Keio University School of MedicineHealth Center, Keio UniversityDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineDivision of Pulmonary Medicine, Department of Medicine, Keio University School of MedicineCenter for Infectious Diseases and Infection Control, Keio University School of MedicineAbstract Background In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of chronic PA infection in MACLD patients. Methods This cross-sectional study was conducted using the Registry of Prospective Cohort Study including MACLD patients. The 36-item Short-Form health survey (SF-36) and St. George’s Respiratory Questionnaire (SGRQ) were administered to assess clinical outcomes. Clinical variables included treatment and sputum culture status, pulmonary function tests, cavitary lesions, and modified Reiff scores on high-resolution computed tomography. Results The study included 244 MACLD patients (median age, 68 years; 196 women), 19 of whom had chronic PA infection. Modified Reiff score was higher in patients with chronic infection than in those without (P = 0.028). Regarding SF-36 scores, physical functioning subscale scores were significantly lower in patients with chronic infection (P = 0.029). Additionally, SGRQ symptoms, impact, and total scores were significantly higher in patients with chronic infection. During analysis of covariance comparisons, SGRQ symptoms and impact scores were significantly higher for patients with chronic infection (P = 0.043 and 0.021, respectively). Conclusions MACLD patients with chronic PA infection exhibited significantly higher SGRQ scores, indicating impaired HRQL. Chronic PA infection was significantly associated with the severity of bronchiectasis.http://link.springer.com/article/10.1186/s12890-017-0544-xColonisationNoncystic fibrosis bronchiectasis (NCFBE)Health-related quality of life (HRQL)Mycobacterium avium Complex (MAC)Nontuberculous mycobacteria (NTM)Pseudomonas aeruginosa |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hirofumi Kamata Takanori Asakura Shoji Suzuki Ho Namkoong Kazuma Yagi Yohei Funatsu Satoshi Okamori Shunsuke Uno Yoshifumi Uwamino Hiroshi Fujiwara Tomoyasu Nishimura Makoto Ishii Tomoko Betsuyaku Naoki Hasegawa |
spellingShingle |
Hirofumi Kamata Takanori Asakura Shoji Suzuki Ho Namkoong Kazuma Yagi Yohei Funatsu Satoshi Okamori Shunsuke Uno Yoshifumi Uwamino Hiroshi Fujiwara Tomoyasu Nishimura Makoto Ishii Tomoko Betsuyaku Naoki Hasegawa Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease BMC Pulmonary Medicine Colonisation Noncystic fibrosis bronchiectasis (NCFBE) Health-related quality of life (HRQL) Mycobacterium avium Complex (MAC) Nontuberculous mycobacteria (NTM) Pseudomonas aeruginosa |
author_facet |
Hirofumi Kamata Takanori Asakura Shoji Suzuki Ho Namkoong Kazuma Yagi Yohei Funatsu Satoshi Okamori Shunsuke Uno Yoshifumi Uwamino Hiroshi Fujiwara Tomoyasu Nishimura Makoto Ishii Tomoko Betsuyaku Naoki Hasegawa |
author_sort |
Hirofumi Kamata |
title |
Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease |
title_short |
Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease |
title_full |
Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease |
title_fullStr |
Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease |
title_full_unstemmed |
Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease |
title_sort |
impact of chronic pseudomonas aeruginosa infection on health-related quality of life in mycobacterium avium complex lung disease |
publisher |
BMC |
series |
BMC Pulmonary Medicine |
issn |
1471-2466 |
publishDate |
2017-12-01 |
description |
Abstract Background In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of chronic PA infection in MACLD patients. Methods This cross-sectional study was conducted using the Registry of Prospective Cohort Study including MACLD patients. The 36-item Short-Form health survey (SF-36) and St. George’s Respiratory Questionnaire (SGRQ) were administered to assess clinical outcomes. Clinical variables included treatment and sputum culture status, pulmonary function tests, cavitary lesions, and modified Reiff scores on high-resolution computed tomography. Results The study included 244 MACLD patients (median age, 68 years; 196 women), 19 of whom had chronic PA infection. Modified Reiff score was higher in patients with chronic infection than in those without (P = 0.028). Regarding SF-36 scores, physical functioning subscale scores were significantly lower in patients with chronic infection (P = 0.029). Additionally, SGRQ symptoms, impact, and total scores were significantly higher in patients with chronic infection. During analysis of covariance comparisons, SGRQ symptoms and impact scores were significantly higher for patients with chronic infection (P = 0.043 and 0.021, respectively). Conclusions MACLD patients with chronic PA infection exhibited significantly higher SGRQ scores, indicating impaired HRQL. Chronic PA infection was significantly associated with the severity of bronchiectasis. |
topic |
Colonisation Noncystic fibrosis bronchiectasis (NCFBE) Health-related quality of life (HRQL) Mycobacterium avium Complex (MAC) Nontuberculous mycobacteria (NTM) Pseudomonas aeruginosa |
url |
http://link.springer.com/article/10.1186/s12890-017-0544-x |
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