In vitro and in vivo safety studies indicate that R15, a synthetic polyarginine peptide, could safely reverse the effects of unfractionated heparin

In vitro and in vivo safety studies indicate that R15, a synthetic polyarginine peptide, could safely reverse the effects of unfractionated heparin

Unfractionated heparin (UFH) is an anionic glycosaminoglycan that is widely used to prevent blood clotting. However, in certain cases, unwanted side effects can require it to be neutralized. Protamine sulfate (PS), a basic peptide rich in arginine, is the only approved antagonist for UFH neutralizat...

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Bibliographic Details
Main Authors: Tong Li, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Taoyun Liu, Peng Han, Jiarui Gao, Su Han, Guifang Dou
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:FEBS Open Bio
Subjects:
heparin reversal
heparin substitutes
immunogenicity
polyarginine
protamine
Online Access:https://doi.org/10.1002/2211-5463.13240

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