Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System
The aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits. The drug delivery system is applied through a modified titanium implant that is configured to be implanted into bone. The implant is hollow and has multiple microholes th...
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2014-01-01
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2014/801358 |
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doaj-f9797598470c46c4bb98d335c8de12a52020-11-25T00:59:06ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/801358801358Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery SystemYoung-Seok Park0Joo-Youn Cho1Shin-Jae Lee2Chee Il Hwang3Department of Oral Anatomy, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-749, Republic of KoreaDepartment of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine, Seoul 110-744, Republic of KoreaDepartment of Orthodontics, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-768, Republic of KoreaDepartment of Orthodontics, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-768, Republic of KoreaThe aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits. The drug delivery system is applied through a modified titanium implant that is configured to be implanted into bone. The implant is hollow and has multiple microholes that can continuously deliver therapeutic agents into the systematic body. To examine the efficacy and feasibility of the IMDDS, we investigated the pharmacokinetic behavior of dexamethasone in plasma after a single dose was delivered via the modified implant placed in the rabbit tibia. After measuring the plasma concentration, the areas under the curve showed that the IMDDS provided a sustained release for a relatively long period. The result suggests that the IMDDS can deliver a sustained release of certain drug components with a high bioavailability. Accordingly, the IMDDS may provide the basis for a novel approach to treating patients with chronic diseases.http://dx.doi.org/10.1155/2014/801358 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Young-Seok Park Joo-Youn Cho Shin-Jae Lee Chee Il Hwang |
spellingShingle |
Young-Seok Park Joo-Youn Cho Shin-Jae Lee Chee Il Hwang Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System BioMed Research International |
author_facet |
Young-Seok Park Joo-Youn Cho Shin-Jae Lee Chee Il Hwang |
author_sort |
Young-Seok Park |
title |
Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System |
title_short |
Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System |
title_full |
Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System |
title_fullStr |
Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System |
title_full_unstemmed |
Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System |
title_sort |
modified titanium implant as a gateway to the human body: the implant mediated drug delivery system |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
The aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits. The drug delivery system is applied through a modified titanium implant that is configured to be implanted into bone. The implant is hollow and has multiple microholes that can continuously deliver therapeutic agents into the systematic body. To examine the efficacy and feasibility of the IMDDS, we investigated the pharmacokinetic behavior of dexamethasone in plasma after a single dose was delivered via the modified implant placed in the rabbit tibia. After measuring the plasma concentration, the areas under the curve showed that the IMDDS provided a sustained release for a relatively long period. The result suggests that the IMDDS can deliver a sustained release of certain drug components with a high bioavailability. Accordingly, the IMDDS may provide the basis for a novel approach to treating patients with chronic diseases. |
url |
http://dx.doi.org/10.1155/2014/801358 |
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