Evaluation of the C60 biodistribution in mice in a micellar ExtraOx form and in an oil solution

Evaluation of the C60 biodistribution in mice in a micellar ExtraOx form and in an oil solution

Abstract The article is devoted to the study of the pharmacokinetics of fullerene C60 in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C60 was found in the liver and adrenal gl...

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Bibliographic Details
Main Authors: Konstantin N. Semenov, Daria A. Ivanova, Sergei V. Ageev, Andrey V. Petrov, Nikita E. Podolsky, Ekaterina M. Volochaeva, Ekaterina M. Fedorova, Anatolii A. Meshcheriakov, Egor E. Zakharov, Igor V. Murin, Vladimir V. Sharoyko
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-87014-3
Description
Summary:Abstract The article is devoted to the study of the pharmacokinetics of fullerene C60 in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C60 was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C60 in the micellar form is higher than that in an oil solution.
ISSN:2045-2322

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