A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression

A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression

Objective: C49 is a chalcone derivative. The aim of the current study is to illuminate the efficacy of C49 in reversing multidrug resistance (MDR) in MCF-7/DOX cells and its underlying molecular mechanism.Methods: The cytotoxic effects of C49 on MCF-7/DOX cells were evaluated by MTT assay using diff...

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Bibliographic Details
Main Authors: Ting Wang, Jingjing Dong, Xu Yuan, Haotian Wen, Linguangjin Wu, Jianwen Liu, Hua Sui, Wanli Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
breast cancer
DOX
C49
multidrug resistance
P-gp
PI3K/akt signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.653306/full

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