PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer

PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer

Background and objective Maintenance of genomic integrity is essential to ensure normal organismal development and to prevent diseases such as cancer. PR-Set7 (also known as Set8) is a cell cycle regulated enzyme that catalyses monomethylation of histone 4 at Lys20 (H4K20me1) to promote chromosome c...

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Bibliographic Details
Main Authors: Yang WANG, Zhidong XU, Jian-Hua MAO, David.HSIEH, Alfred AU, David M. JABLONS, Hui LI, Liang YOU
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2015-06-01
Series:Chinese Journal of Lung Cancer
Subjects:
Lung neoplasms
Cul4A
AdenoCre
Mouse model
PR-Set7
γ-tubulin
Pericentrin
Cell cycle
Online Access:http://dx.doi.org/10.3779/j.issn.1009-3419.2015.06.15

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