Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1
Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass s...
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| Language: | English |
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MDPI AG
2016-03-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/14/3/44 |
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doaj-f998759c2b504e70b0a329651b5f421c2020-11-24T21:36:21ZengMDPI AGMarine Drugs1660-33972016-03-011434410.3390/md14030044md14030044Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1Liu-Qiang Zhang0Xiao-Chong Chen1Zhao-Qiang Chen2Gui-Min Wang3Shi-Guo Zhu4Yi-Fu Yang5Kai-Xian Chen6Xiao-Yu Liu7Yi-Ming Li8School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaShanghai Institute of Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaShanghai Institute of Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaDepartment of Biochemistry and Molecular Biology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, ChinaEutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (1–3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities.http://www.mdpi.com/1660-3397/14/3/44eutypenoidnovel pimarane diterpenesEutypellaArctic fungiimmunosuppressive effect |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Liu-Qiang Zhang Xiao-Chong Chen Zhao-Qiang Chen Gui-Min Wang Shi-Guo Zhu Yi-Fu Yang Kai-Xian Chen Xiao-Yu Liu Yi-Ming Li |
| spellingShingle |
Liu-Qiang Zhang Xiao-Chong Chen Zhao-Qiang Chen Gui-Min Wang Shi-Guo Zhu Yi-Fu Yang Kai-Xian Chen Xiao-Yu Liu Yi-Ming Li Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1 Marine Drugs eutypenoid novel pimarane diterpenes Eutypella Arctic fungi immunosuppressive effect |
| author_facet |
Liu-Qiang Zhang Xiao-Chong Chen Zhao-Qiang Chen Gui-Min Wang Shi-Guo Zhu Yi-Fu Yang Kai-Xian Chen Xiao-Yu Liu Yi-Ming Li |
| author_sort |
Liu-Qiang Zhang |
| title |
Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1 |
| title_short |
Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1 |
| title_full |
Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1 |
| title_fullStr |
Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1 |
| title_full_unstemmed |
Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1 |
| title_sort |
eutypenoids a–c: novel pimarane diterpenoids from the arctic fungus eutypella sp. d-1 |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2016-03-01 |
| description |
Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (1–3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities. |
| topic |
eutypenoid novel pimarane diterpenes Eutypella Arctic fungi immunosuppressive effect |
| url |
http://www.mdpi.com/1660-3397/14/3/44 |
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