Heat Shock Protein 70 in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease that caused dementia which has no effective treatment. Growing evidence has demonstrated that AD is a “protein misfolding disorder” that exhibits common features of misfolded, aggregation-prone proteins and selective cell loss in...
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doaj-f9a108731fa44275a86c09f96c39d8bc2020-11-24T23:32:13ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/435203435203Heat Shock Protein 70 in Alzheimer’s DiseaseRui-Chun Lu0Meng-Shan Tan1Hao Wang2An-Mu Xie3Jin-Tai Yu4Lan Tan5Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, ChinaDepartment of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, ChinaDepartment of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266003, ChinaDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, ChinaDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, ChinaDepartment of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, ChinaAlzheimer’s disease (AD) is the most common neurodegenerative disease that caused dementia which has no effective treatment. Growing evidence has demonstrated that AD is a “protein misfolding disorder” that exhibits common features of misfolded, aggregation-prone proteins and selective cell loss in the mature nervous system. Heat shock protein 70 (HSP70) attracts extensive attention worldwide, because it plays a crucial role in preventing protein misfolding and inhibiting aggregation and represents a class of proteins potentially involved in AD pathogenesis. Numerous studies have indicated that HSP70 could suppress the progression of AD with in vitro and in vivo experiments. Thus, targeting HSP70 and the related compounds might represent a promising strategy for the treatment of AD.http://dx.doi.org/10.1155/2014/435203 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rui-Chun Lu Meng-Shan Tan Hao Wang An-Mu Xie Jin-Tai Yu Lan Tan |
spellingShingle |
Rui-Chun Lu Meng-Shan Tan Hao Wang An-Mu Xie Jin-Tai Yu Lan Tan Heat Shock Protein 70 in Alzheimer’s Disease BioMed Research International |
author_facet |
Rui-Chun Lu Meng-Shan Tan Hao Wang An-Mu Xie Jin-Tai Yu Lan Tan |
author_sort |
Rui-Chun Lu |
title |
Heat Shock Protein 70 in Alzheimer’s Disease |
title_short |
Heat Shock Protein 70 in Alzheimer’s Disease |
title_full |
Heat Shock Protein 70 in Alzheimer’s Disease |
title_fullStr |
Heat Shock Protein 70 in Alzheimer’s Disease |
title_full_unstemmed |
Heat Shock Protein 70 in Alzheimer’s Disease |
title_sort |
heat shock protein 70 in alzheimer’s disease |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Alzheimer’s disease (AD) is the most common neurodegenerative disease that caused dementia which has no effective treatment. Growing evidence has demonstrated that AD is a “protein misfolding disorder” that exhibits common features of misfolded, aggregation-prone proteins and selective cell loss in the mature nervous system. Heat shock protein 70 (HSP70) attracts extensive attention worldwide, because it plays a crucial role in preventing protein misfolding and inhibiting aggregation and represents a class of proteins potentially involved in AD pathogenesis. Numerous studies have indicated that HSP70 could suppress the progression of AD with in vitro and in vivo experiments. Thus, targeting HSP70 and the related compounds might represent a promising strategy for the treatment of AD. |
url |
http://dx.doi.org/10.1155/2014/435203 |
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