Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development

Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development

HPA axis genes implicated in glucocorticoid regulation play an important role in regulating the physiological impact of social and environmental stress, and have become a focal point for investigating the role of glucocorticoid regulation in the etiology of disease. We conducted a systematic review...

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Bibliographic Details
Main Authors: M. Austin Argentieri, Sairaman Nagarajan, Bobak Seddighzadeh, Andrea A. Baccarelli, Alexandra E. Shields
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:EBioMedicine
Subjects:
Methylation
HPA axis
Glucocorticoids
NR3C1
HSD11β2
FKBP5
Adverse childhood experiences (ACE)
Stress
Hypertension
Cancer
PTSD
Depression
Alzheimer's
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417301408

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