The gut microbiota modulates host energy and lipid metabolism in mice[S]

The gut microbiota modulates host energy and lipid metabolism in mice[S]

The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of serum, adipose tissue, and liver of conventionally ra...

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Main Authors: Vidya R. Velagapudi, Rahil Hezaveh, Christopher S. Reigstad, Peddinti Gopalacharyulu, Laxman Yetukuri, Sama Islam, Jenny Felin, Rosie Perkins, Jan Borén, Matej Orešič, Fredrik Bäckhed
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Journal of Lipid Research
Subjects:
metabolomics
lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410661
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spelling doaj-f9a2e7b724a545cc9ea85327e0368bb72021-04-28T06:04:25ZengElsevierJournal of Lipid Research0022-22752010-05-0151511011112The gut microbiota modulates host energy and lipid metabolism in mice[S]Vidya R. Velagapudi0Rahil Hezaveh1Christopher S. Reigstad2Peddinti Gopalacharyulu3Laxman Yetukuri4Sama Islam5Jenny Felin6Rosie Perkins7Jan Borén8Matej Orešič9Fredrik Bäckhed10VTT Technical Research Centre of Finland, Espoo, FI-02044 VTT, FinlandSahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, SE-413 45 Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, SwedenSahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, SE-413 45 Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, SwedenVTT Technical Research Centre of Finland, Espoo, FI-02044 VTT, FinlandVTT Technical Research Centre of Finland, Espoo, FI-02044 VTT, FinlandSahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, SE-413 45 Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, SwedenSahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, SE-413 45 Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, SwedenSahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, SE-413 45 Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, SwedenSahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, SE-413 45 Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, SwedenVTT Technical Research Centre of Finland, Espoo, FI-02044 VTT, Finland; Institute of Molecular Medicine Finland FIMM, Helsinki, FI-00014 University of Helsinki, FinlandTo whom correspondence should be addressed.; Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, SE-413 45 Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, SE-413 45 Gothenburg, SwedenThe gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of serum, adipose tissue, and liver of conventionally raised (CONV-R) and germ-free mice. The serum metabolome of CONV-R mice was characterized by increased levels of energy metabolites, e.g., pyruvic acid, citric acid, fumaric acid, and malic acid, while levels of cholesterol and fatty acids were reduced. We also showed that the microbiota modified a number of lipid species in the serum, adipose tissue, and liver, with its greatest effect on triglyceride and phosphatidylcholine species. Triglyceride levels were lower in serum but higher in adipose tissue and liver of CONV-R mice, consistent with increased lipid clearance. Our findings show that the gut microbiota affects both host energy and lipid metabolism and highlights its role in the development of metabolic diseases.http://www.sciencedirect.com/science/article/pii/S0022227520410661metabolomicslipidomics
collection DOAJ
language English
format Article
sources DOAJ
author Vidya R. Velagapudi
Rahil Hezaveh
Christopher S. Reigstad
Peddinti Gopalacharyulu
Laxman Yetukuri
Sama Islam
Jenny Felin
Rosie Perkins
Jan Borén
Matej Orešič
Fredrik Bäckhed
spellingShingle Vidya R. Velagapudi
Rahil Hezaveh
Christopher S. Reigstad
Peddinti Gopalacharyulu
Laxman Yetukuri
Sama Islam
Jenny Felin
Rosie Perkins
Jan Borén
Matej Orešič
Fredrik Bäckhed
The gut microbiota modulates host energy and lipid metabolism in mice[S]
Journal of Lipid Research
metabolomics
lipidomics
author_facet Vidya R. Velagapudi
Rahil Hezaveh
Christopher S. Reigstad
Peddinti Gopalacharyulu
Laxman Yetukuri
Sama Islam
Jenny Felin
Rosie Perkins
Jan Borén
Matej Orešič
Fredrik Bäckhed
author_sort Vidya R. Velagapudi
title The gut microbiota modulates host energy and lipid metabolism in mice[S]
title_short The gut microbiota modulates host energy and lipid metabolism in mice[S]
title_full The gut microbiota modulates host energy and lipid metabolism in mice[S]
title_fullStr The gut microbiota modulates host energy and lipid metabolism in mice[S]
title_full_unstemmed The gut microbiota modulates host energy and lipid metabolism in mice[S]
title_sort gut microbiota modulates host energy and lipid metabolism in mice[s]
publisher Elsevier
series Journal of Lipid Research
issn 0022-2275
publishDate 2010-05-01
description The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of serum, adipose tissue, and liver of conventionally raised (CONV-R) and germ-free mice. The serum metabolome of CONV-R mice was characterized by increased levels of energy metabolites, e.g., pyruvic acid, citric acid, fumaric acid, and malic acid, while levels of cholesterol and fatty acids were reduced. We also showed that the microbiota modified a number of lipid species in the serum, adipose tissue, and liver, with its greatest effect on triglyceride and phosphatidylcholine species. Triglyceride levels were lower in serum but higher in adipose tissue and liver of CONV-R mice, consistent with increased lipid clearance. Our findings show that the gut microbiota affects both host energy and lipid metabolism and highlights its role in the development of metabolic diseases.
topic metabolomics
lipidomics
url http://www.sciencedirect.com/science/article/pii/S0022227520410661
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